MW 589.7 Da, Purity >98%. Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL.
220127-57-1
> 98%
Solid
589.7 Da
123596
Synthetic
2700049B16Rik, 3110031N04Rik, ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1_HUMAN, ACLS, AHR_HUMAN, AI838772, AIS, ANDR_HUMAN, AR, AR8, AW493413, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Ah receptor, Alpha-type platelet-derived growth factor receptor, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, BCR/ABL FUSION GENE, INCLUDED, BCR/FGFR1 FUSION GENE, INCLUDED, BCR/FGFR1 chimera protein, BCR/PDGFRA FUSION GENE, INCLUDED, BCR1, BCR_HUMAN, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, BXR, Bcr/c abl oncogene protein, Breakpoint cluster region, Breakpoint cluster region protein, C-kit ligand, CAPC, CAR, CAR BETA, CARA, CD117, CD140 antigen-like family member A, CD140A, CD140a antigen, CHNG1, CML, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Car 1, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Class E basic helix-loop-helix protein 76, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, Cytokeratin-associated protein in cancer, Cytosolic NADP-isocitrate dehydrogenase, D22S11, D22S662, DHTR, DNA binding protein, DNA repair protein RAD52, DNA repair protein RAD52 homolog, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Drosophila slowpoke like, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FGFR1/BCR chimera protein, FLJ11090, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HEL-216, HEL-S-26, HGNC:348, HUMARA, HYSP1, Hbeta1, Hbeta2, Hbeta3, Hbeta4, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, JTK7, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, KD, KIT ligand, KIT oncogene, KIT proto oncogene receptor tyrosine kinase, KIT_HUMAN, Kennedy disease (KD), LGR 3, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MB67, MGC104252, MGC112732, MGC22431, MGC57945, MGC74795, MGC75129, MGC97144, MGF, Mast cell growth factor receptor, Mast/stem cell growth factor receptor Kit, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NR1I2_HUMAN, NR1I3_HUMAN, NR3B1, NR3C3, NR3C4, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 1 group I member 3, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, Oxalosuccinate decarboxylase, P150, PAP A, PAPB, PAR, PAR q, PBT, PDGF Receptor alpha, PDGF alpha chain, PDGF-R-alpha, PDGFR 2, PDGFRA, PDGFRA/BCR fusion, PGFRA_HUMAN, PGR, PICD, PPD IV, PR, PRA, PRB, PRGR_HUMAN, PRR, Piebald trait protein, Platelet derived growth factor receptor, Platelet derived growth factor receptor 2, Platelet derived growth factor receptor alpha, Platelet derived growth factor receptor alpha polypeptide, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, Pregnane X receptor, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, Proto oncogene tyrosine protein kinase ABL1, Proto oncogene tyrosine protein kinase Kit, Proto-oncogene c-Abl, Proto-oncogene c-Kit, RAD52 homolog, RAD52 homolog (S. cerevisiae), RAD52_HUMAN, RHEPDGFRA, RP24-311F12.2, Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein, Recombination protein RAD52, Renal carcinoma antigen NY-REN-26, Rhabdomyosarcoma antigen MU RMS 40.23, SAKCA, SBMA, SCAN1, SCF Receptor, SCFR, SLO, SMAX1, SXR, Seven transmembrane helix receptor, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steel Factor Receptor, Stem cell factor receptor, Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TSH Receptor, TSHR_HUMAN, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Tyr-DNA phosphodiesterase 1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Kit, Tyrosyl-DNA phosphodiesterase 1, Zinc finger protein GLI 3, androgen receptor splice variant 4b, bA350O14.10, bHLHe76, bcr/abl, c ABL, c abl oncogene 1 non receptor tyrosine kinase, c abl oncogene 1 receptor tyrosine kinase, c-Kit, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, cytokeratin-associated protein, estrogen receptor related receptor alpha, hERR1, hSlo, hTSHR I, hslo beta, orphan nuclear hormone receptor, p145 c-kit, pregnane X nuclear receptor variant 2, soluble KIT variant 1, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4, v abl, v abl Abelson murine leukemia viral oncogene homolog 1, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MW 589.7 Da, Purity >98%. Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL.
220127-57-1
> 98%
Solid
589.7 Da
123596
Synthetic
Soluble in water to 100 mM. Soluble in DMSO to 100 mM.
Imatinib mesylate
Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL.
CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
YLMAHDNUQAMNNX-UHFFFAOYSA-N
methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Ambient - Can Ship with Ice
-20°C
-20°C
Store under desiccating conditions
This supplementary information is collated from multiple sources and compiled automatically.
The Progesterone Receptor and others like the Aryl Hydrocarbon Receptor c-Kit and TSH Receptor/TSH-R function as key molecules involved in complex signaling and mechanical processes across various tissues. Progesterone Receptor also called PR operates in reproductive tissues while c-Kit also known as CD117 is expressed in hematopoietic cells and plays a role in cell development. These receptors and proteins exhibit different masses such as the Estrogen Related Receptor alpha which has a mass of approximately 54 kDa. Expression of these targets can vary significantly with Androgen Receptor found in high levels in prostate tissues and the Latent TGF-beta Binding Protein (LRRC26) being expressed in the brain and testes.
These targets and proteins such as the Constitutive Androstane Receptor and PDGFR alpha regulate numerous cellular activities ranging from hormone signaling to cell growth and differentiation. c-Kit participates in forming a receptor-ligand complex instrumental for hematopoietic cell survival while the Aryl Hydrocarbon Receptor functions in the detoxification of xenobiotics. RAD52 and TDP1 take part in DNA repair processes where TDP1 helps in resolving DNA breaks. Many of these proteins like Bcr and ABL1 interact within the cytoplasm and nucleus to modulate gene transcription and signal transduction.
Various receptors and channels like the Maxi Potassium channel alpha/SLO are integral to pathways involved in critical cellular processes. Androgen Receptor plays a significant role in the androgen signaling pathway affecting genes that control cell cycle progression. The ABL1 protein is intertwined in the tyrosine kinase signaling pathway which is significant for its role in cell differentiation and proliferation. This intricate network involves other proteins like IDH1 participating in metabolic pathways that influence cellular energy homeostasis as well as interacting with proteins like PXR in xenobiotic metabolism.
These targets are frequently associated with various conditions. The Progesterone Receptor is significantly connected to hormone-driven cancers such as breast cancer while the c-Kit receptor is linked to gastrointestinal stromal tumors (GISTs). Mutations in ABL1 are commonly associated with chronic myeloid leukemia (CML) and its relationship with proteins like Bcr is notable through the Bcr-ABL fusion protein that drives CML. Similarly PDGFR alpha mutations are implicated in the development of certain types of sarcomas highlighting the link between protein dysfunction and disease states.
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2D chemical structure image of ab142070, Imatinib mesylate, Tyrosine kinase inhibitor
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