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MW 383.67 Da, Purity >98%. Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. .

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Publications

Key facts

CAS number
978-62-1
Purity
> 98%
Molecular weight
383.67 Da
Molecular formula
C15H8ClF6NO2
PubChem identifier
5081913
Nature
Synthetic

Target data

Alternative names

ATAD5_HUMAN, ATPase family AAA domain containing 5, ATPase family AAA domain-containing protein 5, C17orf41, Chromosome fragility-associated gene 1 protein, EC 2.7.11.1, ELG1, Enhanced level of genomic instability 1 homolog, FRAG1, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-beta, IKK2, IKKB_HUMAN, IMD15, IMD42, IkBKB, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, KHS, Kinase homologous to SPS1/STE20, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5, MGC129539, NFKBIKB, NR1F3, Nuclear factor NF-kappa-B inhibitor kinase beta, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR, chromosome fragility associated gene 1

Recommended products

MW 383.67 Da, Purity >98%. Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. .

Key facts

Purity
> 98%
PubChem identifier
5081913
Solubility

Soluble in ethanol to 7.74 mM.

Soluble in DMSO to 262.73 mM.

Biochemical name
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
Biological description

Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo.

Canonical SMILES
C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
InChI
InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChIKey
CHILCFMQWMQVAL-UHFFFAOYSA-N
IUPAC name
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

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