IMD 0354, IKKbeta inhibitor

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(5 Publications)

MW 383.67 Da, Purity >98%. Potent, selective cell-permeable IKKβ inhibitor (IC₅₀ = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. .

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ATAD5_HUMAN, ATPase family AAA domain containing 5, ATPase family AAA domain-containing protein 5, C17orf41, Chromosome fragility-associated gene 1 protein, EC 2.7.11.1, ELG1, Enhanced level of genomic instability 1 homolog, FRAG1, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-beta, IKK2, IKKB_HUMAN, IMD15, IMD42, IkBKB, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, KHS, Kinase homologous to SPS1/STE20, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5, MGC129539, NFKBIKB, NR1F3, Nuclear factor NF-kappa-B inhibitor kinase beta, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR, chromosome fragility associated gene 1