MW 68.08 Da. A solution (5 M) of Imidazole buffer in de-ionized water. Achieve your results faster with highly validated, pure and trusted compounds.
288-32-4
Liquid
68.08 Da
C3H4N2
795
Synthetic
51 kDa FK506 binding protein 5, 51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor-associated immunophilin, AIG 6, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP 54, FKBP-51, FKBP5_HUMAN, HEP-NOS, HSP90-binding immunophilin, Hepatocyte NOS, Inducible NO synthase, Inducible NOS, Inducible nitric oxide synthase, MAC NOS, MGC111006, Macrophage NOS, NOS, NOS type II, NOS2A, NOS2A, Inducible, Hepatocyte, NOS2_HUMAN, Nitric oxide synthase, Nitric oxide synthase 2 inducible, Nitric oxide synthase 2 inducible macrophage, Nitric oxide synthase inducible, Nos II, OTTHUMP00000016268, P54, PPIase, PPIase FKBP5, Peptidyl-cysteine S-nitrosylase NOS2, Peptidyl-prolyl cis-trans isomerase FKBP5, Ptg 10, Rotamase, T cell FK506 binding protein, iNOS, inducible, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage, peptidyl-prolyl cis-trans isomerase
MW 68.08 Da. A solution (5 M) of Imidazole buffer in de-ionized water. Achieve your results faster with highly validated, pure and trusted compounds.
288-32-4
Liquid
68.08 Da
C3H4N2
795
Synthetic
In water, 241 g/100 g at 20 °C. In water, 2060 g/kg H2O at 19 °C. In water, 663 g/L at 20 °C. Very soluble in ethanol; soluble in diethyl ether, acetone, pyridine; slightly soluble in benzene. Solubility in water, g/100ml at 20 °C: 63.3 (good).
Imidazole
A solution (5 M) of Imidazole buffer in de-ionized water.
C1=CN=CN1
InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
RAXXELZNTBOGNW-UHFFFAOYSA-N
1H-imidazole
Blue Ice
+4°C
+4°C
This product is manufactured by BioVision, an Abcam company and was previously called B1014 Imidazole (5 M) Solution. B1014-500 is the same size as the 500 ML size of ab285401.
This supplementary information is collated from multiple sources and compiled automatically.
FKBP51 also known as FK506-binding protein 5 or FKBP5 is a immunophilin with a molecular weight of approximately 51 kDa. It forms part of the larger family of FK506-binding proteins and is recognized for its peptidyl-prolyl isomerase activity. This ability allows it to catalyze the interconversion of cis-trans prolyl bonds in peptide chains affecting protein folding and function. FKBP51 is primarily expressed in immune-related tissues such as lymph nodes and thymus as well as in the brain where it influences neural function. Understanding FKBP51's role in cellular processes offers a framework for studying its influence on cell signaling.
FKBP51 modulates the cellular response to stress and glucocorticoid signaling by interacting with hormone receptor complexes. It binds to heat shock proteins and co-chaperones altering their function and stability within these complexes. This interaction impacts the regulation of glucocorticoid receptors a process important for cellular adaptation to stress responses. The presence of FKBP51 in these receptor complexes highlights its regulatory role in hormone signaling which is significant in maintaining cellular homeostasis during stress conditions.
FKBP51 plays a role in the modulation of several critical signaling pathways including the stress response pathway and the inflammation pathway. It regulates the glucocorticoid receptor signaling pathway by modulating receptor sensitivity through chaperone interactions thereby influencing responses to stress and inflammation. FKBP51's interaction with proteins such as Hsp90 a heat shock protein highlights its involvement in these pathways. Through such associations FKBP51 exerts regulatory control over signal transduction processes.
FKBP51 has been linked to the development of stress-related disorders and depression. Altered expression or function of FKBP51 can disrupt glucocorticoid receptor signaling contributing to the pathogenesis of major depressive disorder. FKBP51's interaction with other proteins such as the glucocorticoid receptor demonstrates its relevance in stress-linked conditions. Moreover evidence suggests a role in cancer biology where FKBP51 can influence cell survival and apoptosis. Understanding FKBP51's role in these conditions could provide insights into therapeutic targets for stress and mood disorders.
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