MW 240.3 Da, Purity >95%. Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.
99011-02-6
> 95%
Solid
240.3 Da
C14H16N4
57469
Synthetic
ACLS, ADA1D_HUMAN, ADRA1A, ADRA1L1, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, DNA binding protein, DNA replication inhibitor, GCPS, GEMI_HUMAN, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GMNN, Gastric receptor 1, Gastric receptor I, Geminin, Geminin DNA replication inhibitor, Glioma associated oncogene family zinc finger 3, HGNC:5183, HH2R, HRH2_HUMAN, Histamine H2 receptor, Histamine receptor H2, OTTHUMP00000039393, OTTHUMP00000161242, OTTHUMP00000161243, Oncogene GLI3, PAP A, PAPB, PPD IV, RP3 369A17.3, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3
MW 240.3 Da, Purity >95%. Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.
99011-02-6
> 95%
Solid
240.3 Da
C14H16N4
57469
Synthetic
Soluble in DMSO to 10 mM (with heating).
Imiquimod
Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.
CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
DOUYETYNHWVLEO-UHFFFAOYSA-N
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
Ambient - Can Ship with Ice
-20°C
-20°C
Store under desiccating conditions, The product can be stored for up to 12 months
This product is manufactured by BioVision, an Abcam company and was previously called 1698 Imiquimod. 1698-500 is the same size as the 500 mg size of ab141410.
This supplementary information is collated from multiple sources and compiled automatically.
Alpha 1 Adrenergic Receptor commonly referred to as ADRA1 is a G-protein coupled receptor with an approximate mass of 60 kDa. It mainly resides in smooth muscle cells throughout the vascular system and also in tissues such as the heart and skin. ADRA1 activates through the binding of catecholamines like norepinephrine leading to subsequent cellular responses. This receptor exhibits at least three different subtypes: ADRA1A ADRA1B and ADRA1D each with distinct roles and expression patterns.
Alpha 1 Adrenergic Receptor contributes to a wide array of physiological activities including smooth muscle contraction vasoconstriction and pupil dilation. The receptor does not function in isolation but integrates into signaling complexes that modulate intracellular second messenger systems. As a receptor engaged in various critical physiological functions its expression and activity need precise regulation to ensure homeostasis and effective organismal responses.
Alpha 1 Adrenergic Receptor is deeply entwined in the adrenergic signaling pathway which significantly impacts the cardiovascular and nervous systems. This receptor activates the phospholipase C pathway resulting in the production of inositol triphosphate (IP3) and diacylglycerol (DAG) which ultimately open calcium channels in the endoplasmic reticulum. Through these pathways ADRA1 interacts with other proteins such as ADRA2 and beta-adrenergic receptors contributing to a balanced sympathetic nervous response.
Alpha 1 Adrenergic Receptor plays a role in conditions like hypertension and benign prostatic hyperplasia (BPH). The receptor's involvement in these diseases often relates to its function in vascular and smooth muscle regulation. Overactivation of ADRA1 may contribute to vasoconstriction leading to hypertension while in BPH it can promote muscle contraction around the prostate. Related proteins such as ADRA2 and phospholipase C have also shown implications in these disorders through similar or complementary pathways.
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2D chemical structure image of ab141410, Imiquimod, Toll-like receptor 7 agonist
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