Skip to main content

MW 240.3 Da, Purity >95%. Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.

Be the first to review this product! Submit a review

Images

Chemical Structure - Imiquimod, Toll-like receptor 7 agonist (AB141410), expandable thumbnail

Publications

Key facts

CAS number

99011-02-6

Purity

> 95%

Form

Solid

Molecular weight

240.3 Da

Molecular formula

C14H16N4

PubChem identifier

57469

Nature

Synthetic

Alternative names

Recommended products

MW 240.3 Da, Purity >95%. Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.

Key facts

Purity

> 95%

PubChem identifier

57469

Solubility

Soluble in DMSO to 10 mM (with heating).

Biochemical name

Imiquimod

Biological description

Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.

Canonical SMILES

CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N

InChI

InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)

InChIKey

DOUYETYNHWVLEO-UHFFFAOYSA-N

IUPAC name

1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1698 Imiquimod. 1698-500 is the same size as the 500 mg size of ab141410.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Alpha 1 Adrenergic Receptor commonly referred to as ADRA1 is a G-protein coupled receptor with an approximate mass of 60 kDa. It mainly resides in smooth muscle cells throughout the vascular system and also in tissues such as the heart and skin. ADRA1 activates through the binding of catecholamines like norepinephrine leading to subsequent cellular responses. This receptor exhibits at least three different subtypes: ADRA1A ADRA1B and ADRA1D each with distinct roles and expression patterns.

Biological function summary

Alpha 1 Adrenergic Receptor contributes to a wide array of physiological activities including smooth muscle contraction vasoconstriction and pupil dilation. The receptor does not function in isolation but integrates into signaling complexes that modulate intracellular second messenger systems. As a receptor engaged in various critical physiological functions its expression and activity need precise regulation to ensure homeostasis and effective organismal responses.

Pathways

Alpha 1 Adrenergic Receptor is deeply entwined in the adrenergic signaling pathway which significantly impacts the cardiovascular and nervous systems. This receptor activates the phospholipase C pathway resulting in the production of inositol triphosphate (IP3) and diacylglycerol (DAG) which ultimately open calcium channels in the endoplasmic reticulum. Through these pathways ADRA1 interacts with other proteins such as ADRA2 and beta-adrenergic receptors contributing to a balanced sympathetic nervous response.

Associated diseases and disorders

Alpha 1 Adrenergic Receptor plays a role in conditions like hypertension and benign prostatic hyperplasia (BPH). The receptor's involvement in these diseases often relates to its function in vascular and smooth muscle regulation. Overactivation of ADRA1 may contribute to vasoconstriction leading to hypertension while in BPH it can promote muscle contraction around the prostate. Related proteins such as ADRA2 and phospholipase C have also shown implications in these disorders through similar or complementary pathways.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Imiquimod, Toll-like receptor 7 agonist (ab141410), expandable thumbnail

    Chemical Structure - Imiquimod, Toll-like receptor 7 agonist (ab141410)

    2D chemical structure image of ab141410, Imiquimod, Toll-like receptor 7 agonist

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com