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AB146155

Importazole, nuclear transport receptor importin-beta inhibitor

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(1 Publication)

MW 318.42 g/mol, Purity >99%. Selective nuclear transport receptor importin-β inhibitor (IC50 = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.
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Chemical Structure - Importazole, nuclear transport receptor importin-beta inhibitor (AB146155)
  • Chemical Structure

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Chemical Structure - Importazole, nuclear transport receptor importin-beta inhibitor (AB146155)

2D chemical structure image of ab146155, Importazole, nuclear transport receptor importin-beta inhibitor

Key facts

CAS number

662163-81-7

Purity

>99%

Form

Solid

form

Molecular weight

318.42 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>N<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

Biological description

Selective nuclear transport receptor importin-β inhibitor (IC50 = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.

Canonical smiles

CC(NC1NC(NC2CCCCC12)N3CCCC3)C4CCCCC4

InChi

InChI=1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)

InChiKey

HKGJEZIGDHFJFL-UHFFFAOYSA-N

IUPAC Name

N-(1-Phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging cell 18:e13035 PubMed31532069

2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration.

Applications

Unspecified application

Species

Unspecified reactive species

Mauro Montalbano,Salome McAllen,Urmi Sengupta,Nicha Puangmalai,Nemil Bhatt,Anna Ellsworth,Rakez Kayed
View all publications
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