INCA-6, calcineurin-NFAT interaction inhibitor

Key facts

CAS number

3519-82-2

Purity

>97%

Form

Solid

form

Molecular weight

284.31 g/mol

Molecular formula

C₂₀H₁₂O₂

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biological description

Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor (K_d = 800 nM). Blocks NFAT dephosphorylation, cytokine mRNA induction and nuclear import (~40 μM). Unlike CsA (ab120114) and FK506 (ab120223) INCA-6 does not indiscriminately block other calcineurin substrates. Anti-inflammatory agent. Active in vitro and in vivo.

Canonical smiles

C1=CC=C2C3C4=CC=CC=C4C(C2=C1)C5=C3C(=O)C=CC5=O

InChi

InChI=1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H

InChiKey

GCHPUOHXXCNSQL-UHFFFAOYSA-N

IUPAC Name

9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione