MW 284.31 g/mol, Purity >97%. Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor (Kd = 800 nM). Blocks NFAT dephosphorylation, cytokine mRNA induction and nuclear import (~40 μM). Unlike CsA (ab120114) and FK506 (ab120223) INCA-6 does not indiscriminately block other calcineurin substrates. Anti-inflammatory agent. Active in vitro and in vivo.
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- EMBO molecular medicine 15:e163732022PGF facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR CXC chemokine expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Zhao,Yi Lei,Huying Ning,Yaqiang Zhang,Guilin Chen,Chenchen Wang,Qiangyou Wan,Shumin Guo,Qian Liu,Ruotian Xie,Yujuan Zhuo,Shuai Yan,Jing Zhao,Fengjiang Wei,Lu Wang,Xiaohong Wang,Weidong Li,Hua Yan,Ying YuPubMed 36511116
- Cell reports 31:1076422020Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNatalie K Thulin,R Camille Brewer,Robert Sherwood,Stylianos Bournazos,Karlie G Edwards,Nitya S Ramadoss,Jeffery K Taubenberger,Matthew Memoli,Andrew J Gentles,Prasanna Jagannathan,Sheng Zhang,Daniel H Libraty,Taia T WangPubMed 32402275
- Cardiovascular toxicology 20:261-2802019Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJayeeta Samanta,Arunima Mondal,Srimoyee Saha,Santanu Chakraborty,Arunima SenguptaPubMed 31571030
Key facts
- CAS number
- 3519-82-2
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 284.31 g/mol
- Molecular formula
- C20H12O2
- Nature
- Synthetic
Recommended products
MW 284.31 g/mol, Purity >97%. Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor (Kd = 800 nM). Blocks NFAT dephosphorylation, cytokine mRNA induction and nuclear import (~40 μM). Unlike CsA (ab120114) and FK506 (ab120223) INCA-6 does not indiscriminately block other calcineurin substrates. Anti-inflammatory agent. Active in vitro and in vivo.
Key facts
- CAS number
- 3519-82-2
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 284.31 g/mol
- Molecular formula
- C20H12O2
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 25 mM.
- Biological description
Potent, cell-permeable, selective calcineurin-NFAT interaction inhibitor (Kd = 800 nM). Blocks NFAT dephosphorylation, cytokine mRNA induction and nuclear import (~40 μM). Unlike CsA (ab120114) and FK506 (ab120223) INCA-6 does not indiscriminately block other calcineurin substrates. Anti-inflammatory agent. Active in vitro and in vivo.
- Canonical SMILES
- C1=CC=C2C3C4=CC=CC=C4C(C2=C1)C5=C3C(=O)C=CC5=O
- InChI
- InChI=1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H
- InChIKey
- GCHPUOHXXCNSQL-UHFFFAOYSA-N
- IUPAC name
- 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - INCA-6, calcineurin-NFAT interaction inhibitor (ab145864)
2D chemical structure image of ab145864, INCA-6, calcineurin-NFAT interaction inhibitor
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