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AB141296

Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor.

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(1 Publication)

MW 277.28 g/mol, Purity >98%. Potent GSK3β inhibitor (IC50 = 22 nM). CDK inhibitor (IC50 values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G2/M cell cycle arrest. Prevents tau phosphorylation. Shows neuroprotective effects in vivo. .
1 Images
Chemical Structure - Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor. (AB141296)
  • Chemical Structure

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Chemical Structure - Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor. (AB141296)

2D chemical structure image of ab141296, Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor.

Key facts

CAS number

160807-49-8

Purity

>98%

Molecular weight

277.28 g/mol

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>1</sub>N<sub>3</sub>O<sub>2</sub>

Nature

Synthetic

Biological description

Potent GSK3β inhibitor (IC50 = 22 nM). CDK inhibitor (IC50 values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G2/M cell cycle arrest. Prevents tau phosphorylation. Shows neuroprotective effects in vivo.

Isomeric smiles

O\N=C3/C4CCCCC4N/C3=C1/C2CCCCC2NC1=O

InChi

InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+

InChiKey

HBDSHCUSXQATPO-BGBJRWHRSA-N

IUPAC Name

3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 94: PubMed31723021

2020

Puumala and Andes Orthohantaviruses Cause Transient Protein Kinase R-Dependent Formation of Stress Granules.

Applications

Unspecified application

Species

Unspecified reactive species

Wanda Christ,Janne Tynell,Jonas Klingström
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