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AB120960

Indirubin, cyclin-dependent kinase and GSK-3 beta inhibitor

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MW 262.26 Da, Purity >98%. Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.
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Chemical Structure - Indirubin, cyclin-dependent kinase and GSK-3 beta inhibitor (AB120960)
  • Chemical Structure

Lab

Chemical Structure - Indirubin, cyclin-dependent kinase and GSK-3 beta inhibitor (AB120960)

2D chemical structure image of ab120960, Indirubin, cyclin-dependent kinase and GSK-3 beta inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

262.26 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>0</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

5359405

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

CID 5359405

Biological description

Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.

Canonical smiles

C1=CC=C2C(=C1)C(=C3C(=O)C4=CC=CC=C4N3)C(=O)N2

Isomeric smiles

C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2

InChi

InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13+

InChiKey

CRDNMYFJWFXOCH-BUHFOSPRSA-N

IUPAC Name

(3E)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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