MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
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- The Journal of clinical investigation 123:2475-872013Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNatividad Pozo,Cristina Zahonero,Paloma Fernández,Jose M Liñares,Angel Ayuso,Masatoshi Hagiwara,Angel Pérez,Jose R Ricoy,Aurelio Hernández-Laín,Juan M Sepúlveda,Pilar Sánchez-GómezPubMed 23635774
- Nature communications 1:862010Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYasushi Ogawa et. al.PubMed 20981014
Key facts
- Purity
> 98%
- Form
Solid
- Molecular weight
235.3 Da
- Molecular formula
C12H13NO2S
- PubChem identifier
69538603
- Nature
Synthetic
Target data
Recommended products
MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
Key facts
- Purity
> 98%
- Form
Solid
- Molecular weight
235.3 Da
- Molecular formula
C12H13NO2S
- PubChem identifier
69538603
- Nature
Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
CID 69538603
- Biological description
Potent DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
- Canonical SMILES
CCN1C2=C(C=CC(=C2)O)SC1=CC(=O)C
- InChI
InChI=1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3
- InChIKey
GCSZJMUFYOAHFY-UHFFFAOYSA-N
- IUPAC name
1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
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Chemical Structure - INDY, DYRK1A/B inhibitor (ab223890)
2D chemical structure image of ab223890, INDY, DYRK1A/B inhibitor
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