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AB223890

INDY, DYRK1A/B inhibitor

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(2 Publications)

MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
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Chemical Structure - INDY, DYRK1A/B inhibitor (AB223890)
  • Chemical Structure

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Chemical Structure - INDY, DYRK1A/B inhibitor (AB223890)

2D chemical structure image of ab223890, INDY, DYRK1A/B inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

235.3 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>3</sub>NO<sub>2</sub>S

PubChem

69538603

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CID 69538603

Biological description

Potent DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.

Canonical smiles

CCN1C2=C(C=CC(=C2)O)SC1=CC(=O)C

InChi

InChI=1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3

InChiKey

GCSZJMUFYOAHFY-UHFFFAOYSA-N

IUPAC Name

1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 123:2475-87 PubMed23635774

2013

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.

Applications

Unspecified application

Species

Unspecified reactive species

Natividad Pozo,Cristina Zahonero,Paloma Fernández,Jose M Liñares,Angel Ayuso,Masatoshi Hagiwara,Angel Pérez,Jose R Ricoy,Aurelio Hernández-Laín,Juan M Sepúlveda,Pilar Sánchez-Gómez

Nature communications 1:86 PubMed20981014

2010

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.

Applications

Unspecified application

Species

Unspecified reactive species

Yasushi Ogawa,Yosuke Nonaka,Toshiyasu Goto,Eriko Ohnishi,Toshiyuki Hiramatsu,Isao Kii,Miyo Yoshida,Teikichi Ikura,Hiroshi Onogi,Hiroshi Shibuya,Takamitsu Hosoya,Nobutoshi Ito,Masatoshi Hagiwara
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