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MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).

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Images

Chemical Structure - Iodotubercidin, adenosine kinase inhibitor (AB120452), expandable thumbnail

Publications

Key facts

CAS number
24386-93-4
Purity
> 95%
Form
Solid
Molecular weight
392.15 Da
Molecular formula
C11H13IN4O4
PubChem identifier
46875276
Nature
Synthetic

Target data

Recommended products

MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).

Key facts

Purity
> 95%
PubChem identifier
46875276
Solubility

Soluble in DMSO to 50 mM.

Biochemical name
(3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Biological description

Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).

Canonical SMILES
C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)I
Isomeric SMILES
C1=C(C2=C(N=CN=C2N1C3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)I
InChI
InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11?/m1/s1
InChIKey
WHSIXKUPQCKWBY-YNJARDAQSA-N
IUPAC name
(3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Iodotubercidin, adenosine kinase inhibitor (ab120452), expandable thumbnail

    Chemical Structure - Iodotubercidin, adenosine kinase inhibitor (ab120452)

    2D chemical structure image of ab120452, Iodotubercidin, adenosine kinase inhibitor

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Product protocols

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