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AB120452

Iodotubercidin, adenosine kinase inhibitor

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(1 Publication)

MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
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Chemical Structure - Iodotubercidin, adenosine kinase inhibitor (AB120452)
  • Chemical Structure

Lab

Chemical Structure - Iodotubercidin, adenosine kinase inhibitor (AB120452)

2D chemical structure image of ab120452, Iodotubercidin, adenosine kinase inhibitor

Key facts

CAS number

24386-93-4

Purity

>95%

Form

Solid

form

Molecular weight

392.15 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>3</sub>IN<sub>4</sub>O<sub>4</sub>

PubChem

46875276

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Biological description

Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).

Canonical smiles

C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)I

Isomeric smiles

C1=C(C2=C(N=CN=C2N1C3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)I

InChi

InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11?/m1/s1

InChiKey

WHSIXKUPQCKWBY-YNJARDAQSA-N

IUPAC Name

(3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 9:e98185 PubMed24859235

2014

Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Huang,Fumio Kondo,Masahiko Gosho,Guo-Gang Feng,Misako Harato,Zhong-yuan Xia,Naohisa Ishikawa,Yoshihiro Fujiwara,Shoshiro Okada
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