IOX2, HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor

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MW 352.3 Da, Purity >98%. Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor (IC₅₀ = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.

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C1ORF12, CXXC-type zinc finger protein 8, CXXC8, Chromosome 1 Open Reading Frame 12, DKFZp761F179, DXS1272E, ECYT 3, EGL 9 homolog of C. elegans 1, EGL nine (C.elegans) homolog 1, EGLN1_HUMAN, Egl 9 family hypoxia inducible factor 1, Egl nine homolog 1, Egl nine homolog 1 (C. elegans), Egl nine like protein 1, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, FBL11, FBL7, FBXL11, HIF-P4H 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Histone demethylase JARID1C, Hypoxia-inducible factor prolyl hydroxylase 2, JARID1C, JHDM1A, JmjC domain containing protein SMCX, JmjC domain-containing histone demethylation protein 1A, Jumonji AT rich interactive domain 1C, Jumonji C domain containing histone demethylase 1A, Jumonji, AT rich interactive domain 1C (RBP2 like), Jumonji/ARID domain-containing protein 1C, KDM2A_HUMAN, KDM5C_HUMAN, LILINA, Lysine (K) specific demethylase 2A, Lysine (K) specific demethylase 5C, Lysine-specific demethylase 2A, Lysine-specific demethylase 5C, MRX13, MRXJ, MRXSCJ, MRXSJ, ORF13, P4H2, PHD 2, PNAS 118, PNAS 137, Prolyl hydroxylase domain-containing protein 2, Protein SmcX, Protein Xe169, Rat Homolog of SM20, SM-20, SMCX, Selected cDNA on X, SmcX protein, Smcx homolog X chromosome, Smcy homolog X linked, XE169, Xe169 protein, ZMYND6, Zinc finger MYND domain containing protein 6, [Histone-H3]-lysine-36 demethylase 1A, rbp2 like protein