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AB141014

IPA 3, Group I, p21-activated kinase (PAK) inhibitor

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(1 Publication)

MW 350.5 Da, Purity >97%. Group I, p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM). Non-ATP competitive, allosteric inhibition in vivo. Selectivity over >200 other kinases.

View Alternative Names

1 25 dihydroxyvitamin D3 receptor, 25-dihydroxyvitamin D3 receptor, CBX, CBX1_HUMAN, Chromobox 1, Chromobox homolog 1 (HP1 beta homolog Drosophila ), Chromobox protein homolog 1, Drosophila HP1 beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FH, FUMH_HUMAN, Fumarase, Fumarate hydratase, Fumarate hydratase mitochondrial, HLRCC, HP1 beta, HP1 beta homolog, HP1 beta homolog Drosophila, HP1, Drosophila. homolog of, beta, HP1Hs beta, Heterochromatin protein 1 beta, Heterochromatin protein 1 homolog beta, Heterochromatin protein p25, Human heterochromatin protein p25 mRNA complete cds, LRCC, M31, MCL, MCUL 1, MGC2124, MGC60244, MOD 1, MS709, Member 1, Modifier 1 protein, Multiple hereditary cutaneous leiomyomata, NR1I1, NR3B1, Nuclear receptor subfamily 1 group I member 1, Nuclear receptor subfamily 3 group B member 1, PPP1R163, Protein phosphatase 1, regulatory subunit 163, RGP 4, RGS4_HUMAN, Regulator of G protein signalling 4, Regulator of G-protein signaling 4, SCZD 9, Schizophrenia disorder 9, Steroid hormone receptor ERR1, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor, chromobox homolog 1, estrogen receptor related receptor alpha, hERR1, heterochromatin protein p25 beta, p25beta

1 Images
Chemical Structure - IPA 3, Group I, p21-activated kinase (PAK) inhibitor (AB141014)
  • Chemical Structure

Lab

Chemical Structure - IPA 3, Group I, p21-activated kinase (PAK) inhibitor (AB141014)

2D chemical structure image of ab141014, IPA 3, Group I, p21-activated kinase (PAK) inhibitor

Key facts

CAS number

42521-82-4

Purity

>97%

Form

Solid

form

Molecular weight

350.5 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>4</sub>O<sub>2</sub>S<sub>2</sub>

PubChem

521106

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 25 mM

Biochemical name

Bis(2-hydroxy-1-naphthyl) disulfide

Biological description

Group I, p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM). Non-ATP competitive, allosteric inhibition in vivo. Selectivity over >200 other kinases.

Canonical smiles

C1=CC=C2C(=C1)C=CC(=C2SSC3=C(C=CC4=CC=CC=C43)O)O

InChi

InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H

InChiKey

RFAXLXKIAKIUDT-UHFFFAOYSA-N

IUPAC Name

1-[(2-hydroxynaphthalen-1-yl)disulfanyl]naphthalen-2-ol

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastroenterology 21:9945-56 PubMed26379399

2015

β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Song Liu,Xiang-Ming Che,Shuai Chang,Guang-Lin Qiu,Shi-Cai He,Lin Fan,Wei Zhao,Zheng-Liang Zhang,Shu-Feng Wang
View all publications

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