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AB273621

Ipatasertib (GDC-0068)

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MW 458 Da, Purity >98%. Selective Akt1/2/3 inhibitor (IC50 = 5 nM, 18 nM and 8 nM, respectively). Selective for Akt over PKA (620-fold). ATP-competitive. Antitumor activity in vitro and in vivo.
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Chemical Structure - Ipatasertib (GDC-0068) (AB273621)
  • Chemical Structure

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Chemical Structure - Ipatasertib (GDC-0068) (AB273621)

Chemical structure of Ipatasertib (GDC-0068), 1001264-89-6

Key facts

CAS number

1001264-89-6

Purity

>98%

Form

Solid

form

Molecular weight

458 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>3</sub><sub>2</sub>ClN<sub>5</sub>O<sub>2</sub>

PubChem

24788740

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Ipatasertib

Biological description

Selective Akt1/2/3 inhibitor (IC50 = 5 nM, 18 nM and 8 nM, respectively). Selective for Akt over PKA (620-fold). ATP-competitive. Antitumor activity in vitro and in vivo.

Canonical smiles

CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O

Isomeric smiles

C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O

InChi

InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1

InChiKey

GRZXWCHAXNAUHY-NSISKUIASA-N

IUPAC Name

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Complementary Products

Biochemicals

AB235550

Miransertib, pan-Akt inhibitor

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Biochemicals

AB282438

Capivasertib (AZD5363)

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Proteins & Peptides

AB116412

Recombinant Human AKT1 protein

Western blot - Recombinant Human AKT1 protein (AB116412)

  • 0
  • 0
Assay Kits

AB253299

AKT 1/2/3 pS473 + AKT 1/2/3 Total ELISA Kit

SimpleStep

Sandwich ELISA - AKT 1/2/3 pS473 + AKT 1/2/3 Total ELISA Kit (AB253299)

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  • 1

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