IQ-1S, JNK3 inhibitor

Key facts

CAS number

1421610-21-0

Molecular weight

269.23 Da

Molecular formula

C₁₅H₈N₃NaO

PubChem

72193876

Nature

Synthetic

Solubility

Soluble in DMSO to 5 mM

Biochemical name

Sodium;N-oxidoindeno[1,2-b]quinoxalin-11-imine

Biological description

Selective JNK3 inhibitor (IC₅₀ values are 390, 360 and 87 nM for JNK1, 2 and 3 respectively). Inhibits JNK phosphorylation and NFκB /AP-1 transcriptional activity. Shows immunosuppressant effects in vivo.

Canonical smiles

C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=N[O-].[Na+]

Isomeric smiles

C1=CC=C\2C(=C1)C3=NC4=CC=CC=C4N=C3/C2=N\[O-].[Na+]

InChi

InChI=1S/C15H9N3O.Na/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13;/h1-8,19H;/q;+1/p-1/b18-14-;

IUPAC Name

sodium;N-oxidoindeno[1,2-b]quinoxalin-11-imine