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AB141192

IQDMA, Cell-permeable STAT5 inhibitor

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(4 Publications)

MW 304.39 g/mol, Purity >98%. Cell-permeable STAT5 inhibitor (IC50 = 8 μM). Indoloquinoline derivative. Antineoplastic agent with broad spectrum antitumor activity seen in vitro. Induces cell-cycle arrest at the G2/M phase.
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Chemical Structure - IQDMA, Cell-permeable STAT5 inhibitor (AB141192)
  • Chemical Structure

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Chemical Structure - IQDMA, Cell-permeable STAT5 inhibitor (AB141192)

2D chemical structure image of ab141192, IQDMA, Cell-permeable STAT5 inhibitor

Key facts

CAS number

401463-02-3

Purity

>98%

Form

Solid

form

Molecular weight

304.39 g/mol

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>0</sub>N<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biological description

Cell-permeable STAT5 inhibitor (IC50 = 8 μM). Indoloquinoline derivative. Antineoplastic agent with broad spectrum antitumor activity seen in vitro. Induces cell-cycle arrest at the G2/M phase.

Canonical smiles

CN(C)CCNC2NC1CCCCC1C3NC4CCCCC4C23

InChi

InChI=1S/C19H20N4/c1-23(2)12-11-20-19-17-13-7-3-5-9-15(13)21-18(17)14-8-4-6-10-16(14)22-19/h3-10,21H,11-12H2,1-2H3,(H,20,22)

InChiKey

UROLFQZUYMCOHV-UHFFFAOYSA-N

IUPAC Name

N2-11H-Indolo[3,2-c]quinolin-6-yl-N1,N1-dimethyl-1,2-ethanediamine

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Complementary Products

Secondary Antibodies

AB150155

Donkey Anti-Rat IgG H&L (Alexa Fluor® 647) preadsorbed

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Rat IgG H&L (Alexa Fluor® 647) preadsorbed (AB150155)

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Biochemicals

AB141440

WP1066, JAK/STAT3 inhibitor

Chemical Structure - WP1066, JAK/STAT3 inhibitor (AB141440)

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Primary Antibodies

AB178941

Anti-STAT5b antibody [EPR16671]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-STAT5b antibody [EPR16671] (AB178941)

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Primary Antibodies

AB32364

Anti-STAT5 (phospho Y694) antibody [E208]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 (phospho Y694) antibody [E208] (AB32364)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Signal transduction and targeted therapy 9:352 PubMed39690159

2024

Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Jiang,Jiaqi Wang,Liangyu Lin,Liming Du,Yayun Ding,Fanjun Zheng,Hongzhen Xie,Yu Wang,Mingyuan Hu,Benming Liu,Muhan Xu,Jingjie Zhai,Xuefeng Wang,Jiayin Ye,Wei Cao,Chao Feng,Jingyi Feng,Zongliu Hou,Mingyao Meng,Ju Qiu,Qing Li,Yufang Shi,Ying Wang

American journal of cancer research 12:1129-1142 PubMed35411230

2022

Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a murine brain cancer model.

Applications

Unspecified application

Species

Unspecified reactive species

Chiami Moyama,Mitsugu Fujita,Shota Ando,Keiko Taniguchi,Hiromi Ii,Seisuke Tanigawa,Naoya Hashimoto,Susumu Nakata

Cancer research 80:1102-1117 PubMed31911557

2020

The Immunosuppressive Microenvironment in BRCA1-IRIS-Overexpressing TNBC Tumors Is Induced by Bidirectional Interaction with Tumor-Associated Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Eman Sami,Bibbin T Paul,James A Koziol,Wael M ElShamy

The Journal of steroid biochemistry and molecular biology 185:137-141 PubMed30125658

2018

Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Kiyotaka Itcho,Kenji Oki,Kazuhiro Kobuke,Haruya Ohno,Masayasu Yoneda,Noboru Hattori
View all publications
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