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MW 355.5 Da, Purity >99%. Cell-permeable, selective SCF/c-Kit inhibitor (IC50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo. .

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Images

Chemical Structure - ISCK03, SCF/c-Kit inhibitor (AB145066), expandable thumbnail

Publications

Key facts

CAS number
945526-43-2
Purity
> 99%
Form
Solid
Molecular weight
355.5 Da
Molecular formula
C19H21N3O2S
PubChem identifier
3792751
Nature
Synthetic

Target data

Recommended products

MW 355.5 Da, Purity >99%. Cell-permeable, selective SCF/c-Kit inhibitor (IC50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo. .

Key facts

Purity
> 99%
PubChem identifier
3792751
Solubility

Soluble in ethanol to 25 mM.

Soluble in DMSO to 100 mM.

Biochemical name
tert-Butylphenyl imidazolylphenyl sulfonamide
Biological description

Cell-permeable, selective SCF/c-Kit inhibitor (IC50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo.

Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
InChI
InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
InChIKey
XQABBHBFHWHMKF-UHFFFAOYSA-N
IUPAC name
4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - ISCK03, SCF/c-Kit inhibitor (ab145066), expandable thumbnail

    Chemical Structure - ISCK03, SCF/c-Kit inhibitor (ab145066)

    2D chemical structure image of ab145066, ISCK03, SCF/c-Kit inhibitor

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Product protocols

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