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AB145066

ISCK03, SCF/c-Kit inhibitor

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(1 Publication)

MW 355.5 Da, Purity >99%. Cell-permeable, selective SCF/c-Kit inhibitor (IC50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo. .
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Chemical Structure - ISCK03, SCF/c-Kit inhibitor (AB145066)
  • Chemical Structure

Lab

Chemical Structure - ISCK03, SCF/c-Kit inhibitor (AB145066)

2D chemical structure image of ab145066, ISCK03, SCF/c-Kit inhibitor

Key facts

CAS number

945526-43-2

Purity

>99%

Form

Solid

form

Molecular weight

355.5 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>1</sub>N<sub>3</sub>O<sub>2</sub>S

PubChem

3792751

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

Biochemical name

tert-Butylphenyl imidazolylphenyl sulfonamide

Biological description

Cell-permeable, selective SCF/c-Kit inhibitor (IC50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo.

Canonical smiles

CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3

InChi

InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3

InChiKey

XQABBHBFHWHMKF-UHFFFAOYSA-N

IUPAC Name

4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide

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Complementary Products

Primary Antibodies

AB305299

Anti-TRPV1 antibody [EPR25057-67]

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Western blot - Anti-TRPV1 antibody [EPR25057-67] (AB305299)

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Primary Antibodies

AB210546

Anti-MelanA antibody [EPR20380]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MelanA antibody [EPR20380] (AB210546)

  • 5
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Assay Kits

AB208980

Mouse Von Willebrand Factor A2 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse Von Willebrand Factor A2 ELISA Kit (AB208980)

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Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

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  • 229
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer science 112:655-667 PubMed33247506

2020

c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Ma,Xiaohui Liu,Hong Chen,Muhammad Khawar Abbas,Liu Yang,Haimei Sun,Tingyi Sun,Bo Wu,Shu Yang,Deshan Zhou
View all publications
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Product promise

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