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AB142140

ISO 1, MIF-Antagonist, MIF antagonist

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(5 Publications)

MW 235.24 Da, Purity >99%. Potent, cell-permeable MIF (migration inhibitory factor) antagonist (IC50 = 25 μM). Targets catalytic pocket of MIF. Inhibits TNF release from macrophages. Anti-inflammatory. Active in vitro and in vivo.
1 Images
Chemical Structure - ISO 1, MIF-Antagonist, MIF antagonist (AB142140)
  • Chemical Structure

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Chemical Structure - ISO 1, MIF-Antagonist, MIF antagonist (AB142140)

2D chemical structure image of ab142140, ISO 1, MIF-Antagonist, MIF antagonist

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

235.24 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>3</sub>NO<sub>4</sub>

PubChem

6098948

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

CID 6098948

Biological description

Potent, cell-permeable MIF (migration inhibitory factor) antagonist (IC50 = 25 μM). Targets catalytic pocket of MIF. Inhibits TNF release from macrophages. Anti-inflammatory. Active in vitro and in vivo.

Canonical smiles

COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1

Isomeric smiles

COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1

InChi

InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3

InChiKey

CLVQGFPQFNASJH-UHFFFAOYSA-N

IUPAC Name

methyl 2-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2-oxazolidin-5-yl]acetate

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Primary Antibodies

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Biochemicals

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 5: PubMed35961782

2022

Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuhiro Yamamoto,Ken Kadoya,Mohamad Alaa Terkawi,Takeshi Endo,Kohtarou Konno,Masahiko Watanabe,Satoshi Ichihara,Akira Hara,Kazuo Kaneko,Norimasa Iwasaki,Muneaki Ishijima

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36:e22449 PubMed35839070

2022

MIF confers survival advantage to pancreatic CAFs by suppressing interferon pathway-induced p53-dependent apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Voddu Suresh,Pujarini Dash,Sujit Suklabaidya,Krushna Chandra Murmu,Prakash K Sasmal,Gajendra M Jogdand,Deepti Parida,Manisha Sethi,Biswajit Das,Debasish Mohapatra,Subha Saha,Punit Prasad,Abhay Satoskar,Shantibhusan Senapati

PLoS biology 19:e3001121 PubMed33661886

2021

CD74 is a regulator of hematopoietic stem cell maintenance.

Applications

Unspecified application

Species

Unspecified reactive species

Shirly Becker-Herman,Milena Rozenberg,Carmit Hillel-Karniel,Naama Gil-Yarom,Mattias P Kramer,Avital Barak,Lital Sever,Keren David,Lihi Radomir,Hadas Lewinsky,Michal Levi,Gilgi Friedlander,Richard Bucala,Amnon Peled,Idit Shachar

American journal of physiology. Renal physiology 318:F741-F753 PubMed32068458

2020

Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Naoko Ito,Kazuo Sakamoto,Chihiro Hikichi,Taiji Matsusaka,Michio Nagata

Cell communication and signaling : CCS 16:70 PubMed30348174

2018

Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Mawulikplimi Adzavon,Pengxiang Zhao,Jianmin Ma,Xujuan Zhang,Xin Zhang,Mingzi Zhang,Mengyu Liu,Limin Wang,Danying Chen,Tarekegn Gebreyesus Abisso,Baobei Lv,Lei Wang,Fei Xie,Xuemei Ma
View all publications
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