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AB141168

Isobavachalcone, Akt inhibitor

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(1 Publication)

MW 324.4 Da, Purity >99%. Inhibits Akt activation and subsequent downstream signaling to evoke apoptosis. Constituent of P. longum. Displays antiproliferative and antioxidant activity. Active in vivo.
2 Images
Functional Studies - Isobavachalcone, Akt inhibitor (AB141168)
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Unknown

Functional Studies - Isobavachalcone, Akt inhibitor (AB141168)

ab7977 staining Bax in SK-N-SH cells treated with isobavachalcone (ab141168), by ICC/IF. Increase of Bax expression correlates with increased concentration of isobavachalcone, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141168 (isobavachalcone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Isobavachalcone, Akt inhibitor (AB141168)
  • Chemical Structure

Lab

Chemical Structure - Isobavachalcone, Akt inhibitor (AB141168)

2D chemical structure image of ab141168, Isobavachalcone, Akt inhibitor

Key facts

CAS number

20784-50-3

Purity

>99%

Source

Psoralea corylifolia

Molecular weight

324.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>0</sub>O<sub>4</sub>

PubChem

5281255

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Isobavachalcone

Biological description

Inhibits Akt activation and subsequent downstream signaling to evoke apoptosis. Constituent of P. longum. Displays antiproliferative and antioxidant activity. Active in vivo.

Canonical smiles

CC(=CCC1=C(C=CC(=C1O)C(=O)C=CC2=CC=C(C=C2)O)O)C

Isomeric smiles

CC(=CCC1=C(C=CC(=C1O)C(=O)/C=C/C2=CC=C(C=C2)O)O)C

InChi

InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+

InChiKey

DUWPGRAKHMEPCM-IZZDOVSWSA-N

IUPAC Name

(E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed39887032

2025

Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth.

Applications

Unspecified application

Species

Unspecified reactive species

Flavie Coquel,Sing-Zong Ho,Keng-Chang Tsai,Chun-Yen Yang,Antoine Aze,Julie Devin,Ting-Hsiang Chang,Marie Kong-Hap,Audrey Bioteau,Jerome Moreaux,Domenico Maiorano,Philippe Pourquier,Wen-Chin Yang,Yea-Lih Lin,Philippe Pasero
View all publications
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