MW 324.4 Da, Purity >99%. Inhibits Akt activation and subsequent downstream signaling to evoke apoptosis. Constituent of P. longum. Displays antiproliferative and antioxidant activity. Active in vivo.
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Key facts
- CAS number
- 20784-50-3
- Purity
- > 99%
- Source
- Psoralea corylifolia
- Molecular weight
- 324.4 Da
- Molecular formula
- C20H20O4
- PubChem identifier
- 5281255
- Nature
- Native
Target data
Recommended products
MW 324.4 Da, Purity >99%. Inhibits Akt activation and subsequent downstream signaling to evoke apoptosis. Constituent of P. longum. Displays antiproliferative and antioxidant activity. Active in vivo.
Key facts
- CAS number
- 20784-50-3
- Purity
- > 99%
- Source
- Psoralea corylifolia
- Molecular weight
- 324.4 Da
- Molecular formula
- C20H20O4
- PubChem identifier
- 5281255
- Nature
- Native
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- Isobavachalcone
- Biological description
Inhibits Akt activation and subsequent downstream signaling to evoke apoptosis. Constituent of P. longum. Displays antiproliferative and antioxidant activity. Active in vivo.
- Canonical SMILES
- CC(=CCC1=C(C=CC(=C1O)C(=O)C=CC2=CC=C(C=C2)O)O)C
- Isomeric SMILES
- CC(=CCC1=C(C=CC(=C1O)C(=O)/C=C/C2=CC=C(C=C2)O)O)C
- InChI
- InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
- InChIKey
- DUWPGRAKHMEPCM-IZZDOVSWSA-N
- IUPAC name
- (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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2 product images
Chemical Structure - Isobavachalcone, Akt inhibitor (ab141168)
2D chemical structure image of ab141168, Isobavachalcone, Akt inhibitor
Functional Studies - Isobavachalcone, Akt inhibitor (ab141168)
ab7977 staining Bax in SK-N-SH cells treated with isobavachalcone (ab141168), by ICC/IF. Increase of Bax expression correlates with increased concentration of isobavachalcone, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141168 (isobavachalcone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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