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AB120710

Isoprenaline hydrochloride (Isoproterenol), Non-selective beta adrenoceptor agonist

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MW 247.72 g/mol, Purity >98%. Non-selective β adrenoceptor agonist. Structurally similar to adrenaline. Stimulates MAPK activation through cAMP dependent kinases (EC50 = 1-3 μM). Systemically active upon subcutaneous administration.

Also available in simple stock solutions (ab146724) - add 1 ml of water to get an exact, ready-to-use concentration.
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Functional Studies - Isoprenaline hydrochloride (Isoproterenol), Non-selective beta adrenoceptor agonist (AB120710)
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Functional Studies - Isoprenaline hydrochloride (Isoproterenol), Non-selective beta adrenoceptor agonist (AB120710)

ab62153 staining HSL pSer855 in NIH-3T3 cells treated with isoprenaline hydrochloride (ab120710), by ICC/IF. Increase of HSL pSer855 expression correlates with increased concentration of isoprenaline hydrochloride, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120710 (isoprenaline hydrochloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab62153 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Isoprenaline hydrochloride (Isoproterenol), Non-selective beta adrenoceptor agonist (AB120710)
  • Chemical Structure

Lab

Chemical Structure - Isoprenaline hydrochloride (Isoproterenol), Non-selective beta adrenoceptor agonist (AB120710)

2D chemical structure image of ab120710, Isoprenaline hydrochloride (Isoproterenol), Non-selective beta adrenoceptor agonist

Key facts

CAS number

51-30-9

Purity

>98%

Form

Solid

form

Molecular weight

247.72 g/mol

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>7</sub>NO<sub>3</sub>.HCl

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Non-selective β adrenoceptor agonist. Structurally similar to adrenaline. Stimulates MAPK activation through cAMP dependent kinases (EC50 = 1-3 μM). Systemically active upon subcutaneous administration.

Also available in simple stock solutions (ab146724) - add 1 ml of water to get an exact, ready-to-use concentration.

IUPAC Name

4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Biochemicals

AB146724

Isoprenaline hydrochloride (Isoproterenol) (mM/ml), beta adrenoceptor agonist

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Biochemicals

AB120757

Propranolol hydrochloride, beta adrenoceptor antagonist

Chemical Structure - Propranolol hydrochloride, beta adrenoceptor antagonist (AB120757)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Assay Kits

AB185433

Lipolysis Assay Kit (Colorimetric)

Functional Studies - Lipolysis Assay Kit (Colorimetric) (AB185433)

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  • 1

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