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AB278075

IWP-2

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(3 Publications)

MW 466.6 Da, Purity >98%. Wnt production and PORCN inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

CKI-delta, CKI-epsilon, CKId, CKIe, CSNK 1D, CSNK 1E, Casein Kinase 1 delta, Casein kinase 1 epsilon, Casein kinase I, Casein kinase I delta isoform, Casein kinase I epsilon, Casein kinase I isoform delta, Casein kinase I isoform epsilon, DHOF, Doubletime, Drosophila, homolog of, EC 2.7.11.1, FODH, HCK IE, HCKID, KC1D_HUMAN, KC1E_HUMAN, Lymphocytic choriomeningitis virus, MG61, MGC 10398, MGC29687, POR, PORC, PORCN_HUMAN, Probable protein-cysteine N-palmitoyltransferase porcupine, Protein MG61, Protein Wnt 3a Precursor, Protein Wnt-3a, Protein kinase CK1 delta, WNT3A_HUMAN, Wingless type MMTV integration site family member 3A, epsilon isoform, kinase CK1 epsilon

Key facts

CAS number

686770-61-6

Purity

>98%

Form

Solid

form

Molecular weight

466.6 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>1</sub><sub>8</sub>N<sub>4</sub>O<sub>2</sub>S<sub>3</sub>

PubChem

2155128

Nature

Synthetic

Solubility

Soluble in DMSO to 5 mM with gentle warming

Biochemical name

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Biological description

Wnt production and PORCN inhibitor.

Canonical smiles

CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

InChi

InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)

InChiKey

WRKPZSMRWPJJDH-UHFFFAOYSA-N

IUPAC Name

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

Product protocols

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular and infection microbiology 8:201 PubMed29988402

2018

Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xinwei Feng,Junfeng Lu,Zitian He,Yidan Wang,Fangfang Qi,Rongbiao Pi,Ge Zhang

Immunology 152:265-275 PubMed28556921

2017

Membrane-bound Dickkopf-1 in Foxp3 regulatory T cells suppresses T-cell-mediated autoimmune colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Wook-Jin Chae,Jong-Hyun Park,Octavian Henegariu,Saliha Yilmaz,Liming Hao,Alfred L M Bothwell

Nature chemical biology 5:100-7 PubMed19125156

2009

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Baozhi Chen,Michael E Dodge,Wei Tang,Jianming Lu,Zhiqiang Ma,Chih-Wei Fan,Shuguang Wei,Wayne Hao,Jessica Kilgore,Noelle S Williams,Michael G Roth,James F Amatruda,Chuo Chen,Lawrence Lum
View all publications

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