MW 709.7 Da, Purity >95%. Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC50 = 15 nM). Antitumor and antifungal agent. Active in vitro.
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15 Publications for All applications
- Nature communications 15:5412024Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLinnea Z Drexhage,Shengpan Zhang,Maeva Dupont,Franziska Ragaller,Ellen Sjule,Jose Cabezas-Caballero,Lachlan P Deimel,Helen Robertson,Rebecca A Russell,Omer Dushek,Erdinc Sezgin,Niloofar Karaji,Quentin J SattentauPubMed 38225245
- Biomedicines 11:2023Tensile Overload Injures Human Alveolar Epithelial Cells through YAP/F-Actin/MAPK Signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShan He,Ruihan Liu,Qing Luo,Guanbin SongPubMed 37509472
- Theranostics 12:5034-50502022SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Ma,Rongjun Zou,Wanting Shi,Na Zhou,Shaoxian Chen,Hao Zhou,Xinxin Chen,Yueheng WuPubMed 35836807
- Development (Cambridge, England) 149:2022Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaorei Sai,Yayoi Ikawa,Hiromi Nishimura,Katsutoshi Mizuno,Eriko Kajikawa,Takanobu A Katoh,Toshiya Kimura,Hidetaka Shiratori,Katsuyoshi Takaoka,Hiroshi Hamada,Katsura MinegishiPubMed 35420656
- Cell 184:2212-2228.e122021Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMan Lung Yeung,Jade Lee Lee Teng,Lilong Jia,Chaoyu Zhang,Chengxi Huang,Jian-Piao Cai,Runhong Zhou,Kwok-Hung Chan,Hanjun Zhao,Lin Zhu,Kam-Leung Siu,Sin-Yee Fung,Susan Yung,Tak Mao Chan,Kelvin Kai-Wang To,Jasper Fuk-Woo Chan,Zongwei Cai,Susanna Kar Pui Lau,Zhiwei Chen,Dong-Yan Jin,Patrick Chiu Yat Woo,Kwok-Yung YuenPubMed 33713620
- Scientific reports 11:47892021Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLara-Jane Kepser,Sharof Khudayberdiev,Laura Soto Hinojosa,Chiara Macchi,Massimiliano Ruscica,Elena Marcello,Carsten Culmsee,Robert Grosse,Marco B RustPubMed 33637797
- Virologica Sinica 36:692-7052021Rearrangement of Actin Cytoskeleton by Zika Virus Infection Facilitates Blood-Testis Barrier Hyperpermeability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYiwen Nie,Lixia Hui,Moujian Guo,Wei Yang,Rui Huang,Junsen Chen,Xinyue Wen,Meng Zhao,Ying WuPubMed 33534087
- International journal of molecular medicine 45:151-1612019NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhibo Zheng,Shuai Xiang,Yingjie Wang,Yulei Dong,Zeng Li,Yongbo Xiang,Yanyan Bian,Bin Feng,Bo Yang,Xisheng WengPubMed 31746366
- eLife 8:2019Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuiping Wang et. al.PubMed 31042147
Key facts
- CAS number
- 102396-24-7
- Purity
- > 95%
- Form
- Solid
- Source
- Jaspis splendens
- Molecular weight
- 709.7 Da
- Molecular formula
- C36H45BrN4O6
- PubChem identifier
- 6436289
- Nature
- Native
Target data
Recommended products
MW 709.7 Da, Purity >95%. Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC50 = 15 nM). Antitumor and antifungal agent. Active in vitro.
Key facts
- CAS number
- 102396-24-7
- Purity
- > 95%
- Form
- Solid
- Source
- Jaspis splendens
- Molecular weight
- 709.7 Da
- Molecular formula
- C36H45BrN4O6
- PubChem identifier
- 6436289
- Nature
- Native
- Solubility
Soluble in DMSO.
- Biochemical name
- (4R,7R,10S,13R,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
- Biological description
Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC50 = 15 nM). Antitumor and antifungal agent. Active in vitro.
- Canonical SMILES
- CC1CC(OC(=O)CC(NC(=O)C(N(C(=O)C(NC(=O)C(CC(=C1)C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C
- Isomeric SMILES
- C[C@@H]\1C[C@@H](OC(=O)C[C@@H](NC(=O)[C@H](N(C(=O)[C@@H](NC(=O)[C@@H](C/C(=C1)/C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C
- InChI
- InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22+,23-,24-,30+,31+/m0/s1
- InChIKey
- GQWYWHOHRVVHAP-HZIRKPFGSA-N
- IUPAC name
- (4R,7R,10S,13R,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Jasplakinolide, Actin polymerization and stabilization inducer (ab141409)
2D chemical structure image of ab141409, Jasplakinolide, Actin polymerization and stabilization inducer
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