AB141387

JC-1, Mitochondrial membrane potential dye

Name: JC-1, Mitochondrial membrane potential dye (CAS 3520-43-2) | Abcam
Brand: Abcam Limited
SKU: AB141387
Price: 500 USD
Availability: InStock

Be the first to review this product! Submit a review

(22 Publications)

MW 652.2 Da, Purity >95%. Mitochondrial membrane-potential dye. Exhibits potential-dependent accumulation in mitochondria. Fluorescence emission shift from green (~529 nm) to red (~590 nm). Depolarization is indicated by a decrease in the red/green fluorescence intensity ratio.

1 Images

Chemical Structure - JC-1, Mitochondrial membrane potential dye (AB141387)

Chemical Structure

Lab

Chemical Structure - JC-1, Mitochondrial membrane potential dye (AB141387)

2D chemical structure image of ab141387, JC-1, Mitochondrial membrane potential dye

Key facts

CAS number

3520-43-2

Purity

>95%

Form

Solid

form

Molecular weight

652.2 Da

Molecular formula

C25H27Cl4IN4

PubChem

5492929

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

1,1',3,3'-Tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide

Biological description

Mitochondrial membrane-potential dye. Exhibits potential-dependent accumulation in mitochondria. Fluorescence emission shift from green (~529 nm) to red (~590 nm). Depolarization is indicated by a decrease in the red/green fluorescence intensity ratio.

Canonical smiles

CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-]

Isomeric smiles

CCN1C2=CC(=C(C=C2[N+](=C1/C=C/C=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-]

InChi

InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1

InChiKey

FYNNIUVBDKICAX-UHFFFAOYSA-M

IUPAC Name

5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide

Excitation/Emission

Ex: 519nm, Em: 590nm

style

left-column

style

left-column

Properties and storage information

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

style

left-column

style

left-column

style

left-column

Product protocols

Visit the General protocols
Visit the Troubleshooting

style

left-column

Publications (22)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39596320

2024

Molecular Insights into the Inhibition of Lipid Accumulation in Hepatocytes by Unique Extracts of Ashwagandha.

Applications

Unspecified application

Species

Unspecified reactive species

Dongyang Li,Hanlin Han,Yixin Sun,Huayue Zhang,Ren Yoshitomi,Sunil C Kaul,Renu Wadhwa

Cancers 16: PubMed38927944

2024

Mixtures of Three Mortaparibs with Enhanced Anticancer, Anti-Migration, and Antistress Activities: Molecular Characterization in p53-Null Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Renu Wadhwa,Shi Yang,Hazna Noor Meidinna,Anissa Nofita Sari,Priyanshu Bhargava,Sunil C Kaul

CNS neuroscience & therapeutics 30:e14636 PubMed38430221

2024

Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zhang,Xin Gong

Methods in molecular biology (Clifton, N.J.) 2712:103-115 PubMed37578700

2023

Monitoring Mitochondria Function in Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Fangquan Chen,Jiao Liu,Daolin Tang,Rui Kang

Cell death and differentiation 30:369-382 PubMed36443440

2022

SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.

Applications

Unspecified application

Species

Unspecified reactive species

Di Wang,Weiwei Liang,Di Huo,Hongyong Wang,Ying Wang,Chaohua Cong,Chunting Zhang,Shi Yan,Ming Gao,Xiaoli Su,Xingli Tan,Wenmo Zhang,Ling Han,Dongmei Zhang,Honglin Feng

Molecular biology reports 50:961-970 PubMed36376538

2022

HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via inactivation of the MKK3/MAPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiexia Ding,Lili Wu,Guoxian Zhu,Jing Zhu,Pingping Luo,Youming Li

Nature 607:756-761 PubMed35859172

2022

Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I.

Applications

Unspecified application

Species

Unspecified reactive species

Aida Rodríguez-Nuevo,Ariadna Torres-Sanchez,Juan M Duran,Cristian De Guirior,Maria Angeles Martínez-Zamora,Elvan Böke

Disease markers 2022:5186252 PubMed35664430

2022

Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinson's Disease Pathogenesis via Pink1/Parkin-Dependent Mitophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaolin Dong,Xianghua He,Li Yang,Qingyun Li,Yanming Xu

Molecules (Basel, Switzerland) 27: PubMed35011307

2021

Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C.

Applications

Unspecified application

Species

Unspecified reactive species

Ashish Kaul,Raviprasad Kuthethur,Yoshiyuki Ishida,Keiji Terao,Renu Wadhwa,Sunil C Kaul

Journal of inflammation (London, England) 18:31 PubMed34930287

2021

Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Pan Wu,Xiao Yu,Yue Peng,Qian-Lu Wang,Long-Tian Deng,Wei Xing

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

JC-1, Mitochondrial membrane potential dye

Chemical Structure - JC-1, Mitochondrial membrane potential dye (AB141387)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

Isomeric smiles

InChi

InChiKey

IUPAC Name

Excitation/Emission

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (22)

Complementary Products

Secondary Antibodies

Primary Antibodies

Assay Kits

Biochemicals

Product promise