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MW 394.8 Da, Purity >99%. Highly selective H4 receptor silent antagonist (Ki = 26 nM). Shows >540-fold selectivity over the H3 receptor (Ki = 14.1 µM). Orally active *in vivo*.

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Images

Chemical Structure - JNJ 10191584 maleate (VUF 6002), Selective H4 antagonist (AB120191), expandable thumbnail

Key facts

CAS number
869497-75-6
Purity
> 99%
Form
Solid
Molecular weight
394.8 Da
Molecular formula
C17H19ClN4O5
PubChem identifier
11718163
Nature
Synthetic

Target data

Recommended products

MW 394.8 Da, Purity >99%. Highly selective H4 receptor silent antagonist (Ki = 26 nM). Shows >540-fold selectivity over the H3 receptor (Ki = 14.1 µM). Orally active *in vivo*.

Key facts

Purity
> 99%
PubChem identifier
11718163
Solubility

Soluble in DMSO to 50 mM.

Biochemical name
1-[(5-Chloro-1H-benzimidazol-2-YL)carbonyl]-4-methylpiperazine maleate
Biological description

Highly selective H4 receptor silent antagonist (Ki = 26 nM). Shows >540-fold selectivity over the H3 receptor (Ki = 14.1 µM). Orally active *in vivo*.

Canonical SMILES
CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl.C(=CC(=O)O)C(=O)O
Isomeric SMILES
CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl.C(=C\C(=O)O)\C(=O)O
InChI
InChI=1S/C13H15ClN4O.C4H4O4/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12;5-3(6)1-2-4(7)8/h2-3,8H,4-7H2,1H3,(H,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
KOTJFAYEELTYCZ-BTJKTKAUSA-N
IUPAC name
(Z)-but-2-enedioic acid;(6-chloro-1H-benzimidazol-2-yl)-(4-methylpiperazin-1-yl)methanone

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - JNJ 10191584 maleate (VUF 6002), Selective H4 antagonist (ab120191), expandable thumbnail

    Chemical Structure - JNJ 10191584 maleate (VUF 6002), Selective H4 antagonist (ab120191)

    2D chemical structure image of ab120191, JNJ 10191584 maleate (VUF 6002), Selective H4 antagonist

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Product protocols

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