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AB144405

JNJ-7777120, histamine H4 receptor antagonist

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(1 Publication)

MW 277.75 Da, Purity >98%. Potent, highly selective histamine H4 receptor antagonist (Ki = 4.5 nM). Shows anti-inflammatory, antifibrotic and antiallergic effects *in vivo.*.

Key facts

CAS number

459168-41-3

Purity

>98%

Form

Solid

form

Molecular weight

277.75 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>6</sub>ClN<sub>3</sub>O

PubChem

4908365

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Soluble in 1 eq. HCl to 100 mM

Biochemical name

1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine

Biological description

Potent, highly selective histamine H4 receptor antagonist (Ki = 4.5 nM). Shows anti-inflammatory, antifibrotic and antiallergic effects *in vivo.*

Canonical smiles

CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl

InChi

InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3

InChiKey

HUQJRYMLJBBEDO-UHFFFAOYSA-N

IUPAC Name

(5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of innate immunity :1-21 PubMed35858582

2022

Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil's Antimicrobial Response by Engaging the Histamine 2 Receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Karim Dib,Amal El Banna,Clara Radulescu,Guillermo Lopez Campos,Gerard Sheehan,Kevin Kavanagh
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