MW 457 Da, Purity >99%. Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).
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Publications
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- Cancer science 113:1208-12192022Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuka Matsuda,Sho Ikeda,Fumito Abe,Yuto Takahashi,Akihiro Kitadate,Naoto Takahashi,Hideki Wakui,Hiroyuki TagawaPubMed 35133054
- Nature microbiology 7:154-1682021Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJonas D Albarnaz,Hongwei Ren,Alice A Torres,Evgeniya V Shmeleva,Carlos A Melo,Andrew J Bannister,Matthew P Brember,Betty Y-W Chung,Geoffrey L SmithPubMed 34949827
- British journal of cancer 123:580-5902020BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTatsuro Yamamoto et. al.PubMed 32499570
- Scientific reports 8:105902018Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEungyoung Kim et. al.PubMed 30002430
- The Journal of neuroscience : the official journal of the Society for Neuroscience 36:10425-104392016Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarco Kramer,Diogo Ribeiro,Marie Arsenian-Henriksson,Thomas Deller,Hermann RohrerPubMed 27707976
Key facts
- CAS number
- 1268524-70-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 457 Da
- Molecular formula
- C23H25ClN4O2S
- PubChem identifier
- 46907787
- Nature
- Synthetic
Target data
Alternative names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, BRD 6, BRD2_HUMAN, BRD3_HUMAN, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Bromodomain containing 2, Bromodomain containing 3, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CAP, CBP_HUMAN, CP2C9_HUMAN, CPC9, CREB-binding protein, CT9, CYP2C, CYP2C10, CYP2C19, CYPIIC17, CYPIIC19, CYPIIC9, Cancer/testis antigen 9, Cyclic AMP responsive enhancer binding protein, Cytochrome P-450MP, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-11A, Cytochrome P450-254C, D6S113E, DKFZp686N0336, FLJ31942, FSH, FSRG1, Female sterile homeotic related gene 1, Female sterile homeotic related gene 1, mouse, homolog of, HUNK1, HUNKI, KAT3A, KIAA0043, KIAA9001, MCAP, MGC149605, MGC88320, Mephenytoin 4-hydroxylase, Microsomal monooxygenase, Mitotic chromosome-associated protein, NAT, O27.1.1, ORFX, OTTHUMP00000020135, Open reading frame X, P450 MP, P450 PB 1, P450IIC9, Protein HUNK1, RING3, RING3 PROTEIN, RING3 like gene, RING3-like protein, RING3L, RNF3, RSTS, RTS, Really interesting new gene 3 protein, Rubinstein Taybi syndrome, S-mephenytoin 4-hydroxylase, Testis specific bromodomain protein, Xenobiotic monooxygenase, chromosome associated protein, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase
Recommended products
MW 457 Da, Purity >99%. Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).
Key facts
- CAS number
- 1268524-70-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 457 Da
- Molecular formula
- C23H25ClN4O2S
- PubChem identifier
- 46907787
- Nature
- Synthetic
- Biochemical name
- (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- Biological description
Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).
- Canonical SMILES
- CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
- Isomeric SMILES
- CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
- InChI
- InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
- InChIKey
- DNVXATUJJDPFDM-KRWDZBQOSA-N
- IUPAC name
- tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - (+)-JQ1, BET bromodomain inhibitor (ab141498)
2D chemical structure image of ab141498, (+)-JQ1, BET bromodomain inhibitor
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