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MW 457 Da, Purity >99%. Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).

Also available as a solid (ab141498).

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Images

Chemical Structure - (+)-JQ1, BET bromodomain inhibitor (AB141498), expandable thumbnail

Publications

  • Cancer science 113:1208-12192022
    Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Yuka Matsuda,Sho Ikeda,Fumito Abe,Yuto Takahashi,Akihiro Kitadate,Naoto Takahashi,Hideki Wakui,Hiroyuki Tagawa
    PubMed 35133054
  • Nature microbiology 7:154-1682021
    Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Jonas D Albarnaz,Hongwei Ren,Alice A Torres,Evgeniya V Shmeleva,Carlos A Melo,Andrew J Bannister,Matthew P Brember,Betty Y-W Chung,Geoffrey L Smith
    PubMed 34949827

Key facts

CAS number

1268524-70-4

Purity

> 99%

Form

Solid

Molecular weight

457 Da

Molecular formula

C23H25ClN4O2S

PubChem identifier

46907787

Nature

Synthetic

Target data

Alternative names

(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, BRD 6, BRD2_HUMAN, BRD3_HUMAN, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Bromodomain containing 2, Bromodomain containing 3, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CAP, CBP_HUMAN, CP2C9_HUMAN, CPC9, CREB-binding protein, CT9, CYP2C, CYP2C10, CYP2C19, CYPIIC17, CYPIIC19, CYPIIC9, Cancer/testis antigen 9, Cyclic AMP responsive enhancer binding protein, Cytochrome P-450MP, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-11A, Cytochrome P450-254C, D6S113E, DKFZp686N0336, FLJ31942, FSH, FSRG1, Female sterile homeotic related gene 1, Female sterile homeotic related gene 1, mouse, homolog of, HUNK1, HUNKI, KAT3A, KIAA0043, KIAA9001, MCAP, MGC149605, MGC88320, Mephenytoin 4-hydroxylase, Microsomal monooxygenase, Mitotic chromosome-associated protein, NAT, O27.1.1, ORFX, OTTHUMP00000020135, Open reading frame X, P450 MP, P450 PB 1, P450IIC9, Protein HUNK1, RING3, RING3 PROTEIN, RING3 like gene, RING3-like protein, RING3L, RNF3, RSTS, RTS, Really interesting new gene 3 protein, Rubinstein Taybi syndrome, S-mephenytoin 4-hydroxylase, Testis specific bromodomain protein, Xenobiotic monooxygenase, chromosome associated protein, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase

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MW 457 Da, Purity >99%. Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).

Also available as a solid (ab141498).

Alternative names

(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, BRD 6, BRD2_HUMAN, BRD3_HUMAN, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Bromodomain containing 2, Bromodomain containing 3, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CAP, CBP_HUMAN, CP2C9_HUMAN, CPC9, CREB-binding protein, CT9, CYP2C, CYP2C10, CYP2C19, CYPIIC17, CYPIIC19, CYPIIC9, Cancer/testis antigen 9, Cyclic AMP responsive enhancer binding protein, Cytochrome P-450MP, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-11A, Cytochrome P450-254C, D6S113E, DKFZp686N0336, FLJ31942, FSH, FSRG1, Female sterile homeotic related gene 1, Female sterile homeotic related gene 1, mouse, homolog of, HUNK1, HUNKI, KAT3A, KIAA0043, KIAA9001, MCAP, MGC149605, MGC88320, Mephenytoin 4-hydroxylase, Microsomal monooxygenase, Mitotic chromosome-associated protein, NAT, O27.1.1, ORFX, OTTHUMP00000020135, Open reading frame X, P450 MP, P450 PB 1, P450IIC9, Protein HUNK1, RING3, RING3 PROTEIN, RING3 like gene, RING3-like protein, RING3L, RNF3, RSTS, RTS, Really interesting new gene 3 protein, Rubinstein Taybi syndrome, S-mephenytoin 4-hydroxylase, Testis specific bromodomain protein, Xenobiotic monooxygenase, chromosome associated protein, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase

Key facts

Purity

> 99%

PubChem identifier

46907787

Biochemical name

(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Biological description

Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).

Also available as a solid (ab141498).

Canonical SMILES

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

Isomeric SMILES

CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

InChI

InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1

InChIKey

DNVXATUJJDPFDM-KRWDZBQOSA-N

IUPAC name

tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - (+)-JQ1, BET bromodomain inhibitor (ab141498), expandable thumbnail

    Chemical Structure - (+)-JQ1, BET bromodomain inhibitor (ab141498)

    2D chemical structure image of ab141498, (+)-JQ1, BET bromodomain inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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