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AB141498

(+)-JQ1, BET bromodomain inhibitor

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(5 Publications)

MW 457 Da, Purity >99%. Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).

View Alternative Names

(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, BRD 6, BRD2_HUMAN, BRD3_HUMAN, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Bromodomain containing 2, Bromodomain containing 3, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CAP, CBP_HUMAN, CP2C9_HUMAN, CPC9, CREB-binding protein, CT9, CYP2C, CYP2C10, CYP2C19, CYPIIC17, CYPIIC19, CYPIIC9, Cancer/testis antigen 9, Cyclic AMP responsive enhancer binding protein, Cytochrome P-450MP, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-11A, Cytochrome P450-254C, D6S113E, DKFZp686N0336, FLJ31942, FSH, FSRG1, Female sterile homeotic related gene 1, Female sterile homeotic related gene 1, mouse, homolog of, HUNK1, HUNKI, KAT3A, KIAA0043, KIAA9001, MCAP, MGC149605, MGC88320, Mephenytoin 4-hydroxylase, Microsomal monooxygenase, Mitotic chromosome-associated protein, NAT, O27.1.1, ORFX, OTTHUMP00000020135, Open reading frame X, P450 MP, P450 PB 1, P450IIC9, Protein HUNK1, RING3, RING3 PROTEIN, RING3 like gene, RING3-like protein, RING3L, RNF3, RSTS, RTS, Really interesting new gene 3 protein, Rubinstein Taybi syndrome, S-mephenytoin 4-hydroxylase, Testis specific bromodomain protein, Xenobiotic monooxygenase, chromosome associated protein, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase

1 Images
Chemical Structure - (+)-JQ1, BET bromodomain inhibitor (AB141498)
  • Chemical Structure

Lab

Chemical Structure - (+)-JQ1, BET bromodomain inhibitor (AB141498)

2D chemical structure image of ab141498, (+)-JQ1, BET bromodomain inhibitor

Key facts

CAS number

1268524-70-4

Purity

>99%

Form

Solid

form

Molecular weight

457 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>5</sub>ClN<sub>4</sub>O<sub>2</sub>S

PubChem

46907787

Nature

Synthetic

Biochemical name

(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Biological description

Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).

Canonical smiles

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

Isomeric smiles

CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

InChi

InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1

InChiKey

DNVXATUJJDPFDM-KRWDZBQOSA-N

IUPAC Name

tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cancer science 113:1208-1219 PubMed35133054

2022

Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuka Matsuda,Sho Ikeda,Fumito Abe,Yuto Takahashi,Akihiro Kitadate,Naoto Takahashi,Hideki Wakui,Hiroyuki Tagawa

Nature microbiology 7:154-168 PubMed34949827

2021

Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses.

Applications

Unspecified application

Species

Unspecified reactive species

Jonas D Albarnaz,Hongwei Ren,Alice A Torres,Evgeniya V Shmeleva,Carlos A Melo,Andrew J Bannister,Matthew P Brember,Betty Y-W Chung,Geoffrey L Smith

British journal of cancer 123:580-590 PubMed32499570

2020

BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuro Yamamoto,Akiyuki Hirosue,Masafumi Nakamoto,Ryoji Yoshida,Junki Sakata,Yuichiro Matsuoka,Kenta Kawahara,Yuka Nagao,Masashi Nagata,Nozomu Takahashi,Akimitsu Hiraki,Masanori Shinohara,Mitsuyoshi Nakao,Noriko Saitoh,Hideki Nakayama

Scientific reports 8:10590 PubMed30002430

2018

Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Eungyoung Kim,Jehyun Nam,Woochul Chang,Ismayil S Zulfugarov,Zhanna M Okhlopkova,Daniil Olennikov,Nadezhda K Chirikova,Sang-Woo Kim

The Journal of neuroscience : the official journal of the Society for Neuroscience 36:10425-10439 PubMed27707976

2016

Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Kramer,Diogo Ribeiro,Marie Arsenian-Henriksson,Thomas Deller,Hermann Rohrer
View all publications

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