(+)-JQ1 (DMSO solution), BET bromodomain inhibitor
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(1 Publication)
MW 457 Da, Purity >99%. Potent, selective and cell-permeable BET bromodomain inhibitor (Kd values are 50 and 90 nM at BRD4 first and second bromodomains, respectively).
View Alternative Names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, BRD 6, BRD2_HUMAN, BRD3_HUMAN, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Bromodomain containing 2, Bromodomain containing 3, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CAP, CBP_HUMAN, CP2C9_HUMAN, CPC9, CREB-binding protein, CT9, CYP2C, CYP2C10, CYP2C19, CYPIIC17, CYPIIC19, CYPIIC9, Cancer/testis antigen 9, Cyclic AMP responsive enhancer binding protein, Cytochrome P-450MP, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-11A, Cytochrome P450-254C, D6S113E, DKFZp686N0336, FLJ31942, FSH, FSRG1, Female sterile homeotic related gene 1, Female sterile homeotic related gene 1, mouse, homolog of, HUNK1, HUNKI, KAT3A, KIAA0043, KIAA9001, MCAP, MGC149605, MGC88320, Mephenytoin 4-hydroxylase, Microsomal monooxygenase, Mitotic chromosome-associated protein, NAT, O27.1.1, ORFX, OTTHUMP00000020135, Open reading frame X, P450 MP, P450 PB 1, P450IIC9, Protein HUNK1, RING3, RING3 PROTEIN, RING3 like gene, RING3-like protein, RING3L, RNF3, RSTS, RTS, Really interesting new gene 3 protein, Rubinstein Taybi syndrome, S-mephenytoin 4-hydroxylase, Testis specific bromodomain protein, Xenobiotic monooxygenase, chromosome associated protein, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase
- Chemical Structure
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Chemical Structure - (+)-JQ1 (DMSO solution), BET bromodomain inhibitor (AB146612)
2D chemical structure image of ab146612, (+)-JQ1 (DMSO solution), BET bromodomain inhibitor
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins play significant roles in transcriptional regulation and chromatin remodeling. CREBBP exists as part of a transcriptional co-activator complex modifying chromatin structure to facilitate transcription factor binding. BRD2 BRD3 BRDT and Brd4 through their bromodomains recognize and bind acetylated lysines on histones recruiting transcriptional complexes to specific gene promoters. These actions impact gene expression critical for cell cycle progression differentiation and apoptosis.
Pathways
These proteins integrate into large transcriptional and signaling frameworks. They are vital participants in the Notch and Wnt signaling pathways. CREBBP interacts with proteins like p300 functioning in histone acetylation and gene transcription activation. BET proteins such as Brd4 associate with transcription factors and mediate cell cycle transitions by regulating cyclin and c-myc expression. Their roles in these pathways underline their importance in cellular proliferation and development.
Publications (1)
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Cancer discovery 11:384-407 PubMed33158843
2020
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