MW 240.34 Da, Purity >99%. NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo. .
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- Acta cirurgica brasileira 38:e3851232023Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunyu Lai,Xing Liu,Hongwei Su,Yongsheng Zhu,Ke Xin,Mingwei Huang,Songtao Luo,Hai TangPubMed 38055393
- Cell reports 38:1103092022Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChris S Mantsounga,Cadence Lee,Jade Neverson,Sheila Sharma,Abigail Healy,Joshua M Berus,Crystal Parry,Nicolle M Ceneri,Francesc López-Giráldez,Hyung J Chun,Qing Lu,Frank Sellke,Gaurav Choudhary,Alan R MorrisonPubMed 35108537
- Scientific reports 11:182372021KCTD15 deregulation is associated with alterations of the NF-κB signaling in both pathological and physiological model systems.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiovanni Smaldone,Luigi Coppola,Katia Pane,Monica Franzese,Giuliana Beneduce,Rosanna Parasole,Giuseppe Menna,Luigi Vitagliano,Marco Salvatore,Peppino MirabelliPubMed 34521919
- Journal of cellular and molecular medicine 25:6773-67852021Pro-inflammatory signals induce 20α-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLubna Nadeem,Rathesh Balendran,Anna Dorogin,Sam Mesiano,Oksana Shynlova,Stephen J LyePubMed 34114342
- Cell death & disease 11:10042020Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChiara R Battaglia et. al.PubMed 33230105
- Molecular psychiatry :2020A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSilvia Cursano et. al.PubMed 32051550
- PloS one 14:e02250662019Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMinori Kubota et. al.PubMed 31703091
- Cells 8:2019An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGastón Barbero et. al.PubMed 31510045
- Biochimica et biophysica acta. Molecular basis of 1865:2403-24102019Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunyu Lai et. al.PubMed 31102789
Key facts
- CAS number
- 749886-87-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 240.34 Da
- Molecular formula
- C16H20N2
- PubChem identifier
- 16760588
- Nature
- Synthetic
Recommended products
MW 240.34 Da, Purity >99%. NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo. .
Key facts
- CAS number
- 749886-87-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 240.34 Da
- Molecular formula
- C16H20N2
- PubChem identifier
- 16760588
- Nature
- Synthetic
- Solubility
≥24 mg/mL in DMSO.
≥17.1 mg/mL in EtOH.
- Biochemical name
- 4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine
- Biological description
NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo.
- Canonical SMILES
- CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N
- InChI
- InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
- InChIKey
- YMFNPBSZFWXMAD-UHFFFAOYSA-N
- IUPAC name
- 4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions
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1 product image
Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (ab144824)
2D chemical structure image of ab144824, JSH 23, NFkappaB transcriptional activity inhibitor
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