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AB144824

JSH 23, NFkappaB transcriptional activity inhibitor

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(11 Publications)

MW 240.34 Da, Purity >99%. NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo. .
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Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (AB144824)
  • Chemical Structure

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Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (AB144824)

2D chemical structure image of ab144824, JSH 23, NFkappaB transcriptional activity inhibitor

Key facts

CAS number

749886-87-1

Purity

>99%

Form

Solid

form

Molecular weight

240.34 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>

PubChem

16760588

Nature

Synthetic

Solubility

≥24 mg/mL in DMSO

≥17.1 mg/mL in EtOH

Biochemical name

4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine

Biological description

NFκB transcriptional activity inhibitor (IC50 = 7.1 μM). Inhibits LPS-induced nuclear translocation of NFκB. Does not affect IκB degradation. Potentiates the antitumor effects of cisplatin (ab141398). Shows neuroprotective effects in vivo.

Canonical smiles

CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N

InChi

InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

InChiKey

YMFNPBSZFWXMAD-UHFFFAOYSA-N

IUPAC Name

4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 12: PubMed38927430

2024

SARS-CoV-2 Spike Protein 1 Causes Aggregation of α-Synuclein via Microglia-Induced Inflammation and Production of Mitochondrial ROS: Potential Therapeutic Applications of Metformin.

Applications

Unspecified application

Species

Unspecified reactive species

Moon Han Chang,Jung Hyun Park,Hye Kyung Lee,Ji Young Choi,Young Ho Koh

Cell reports 42:113556 PubMed38096050

2023

NK cells propagate T cell immunity following in situ tumor vaccination.

Applications

Unspecified application

Species

Unspecified reactive species

Won Jong Jin,Justin C Jagodinsky,Jessica M Vera,Paul A Clark,Cindy L Zuleger,Amy K Erbe,Irene M Ong,Trang Le,Kaitlin Tetreault,Tracy Berg,Alexander L Rakhmilevich,KyungMann Kim,Michael A Newton,Mark R Albertini,Paul M Sondel,Zachary S Morris

Acta cirurgica brasileira 38:e385123 PubMed38055393

2023

Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3.

Applications

Unspecified application

Species

Unspecified reactive species

Junyu Lai,Xing Liu,Hongwei Su,Yongsheng Zhu,Ke Xin,Mingwei Huang,Songtao Luo,Hai Tang

Cell reports 38:110309 PubMed35108537

2022

Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A.

Applications

Unspecified application

Species

Unspecified reactive species

Chris S Mantsounga,Cadence Lee,Jade Neverson,Sheila Sharma,Abigail Healy,Joshua M Berus,Crystal Parry,Nicolle M Ceneri,Francesc López-Giráldez,Hyung J Chun,Qing Lu,Frank Sellke,Gaurav Choudhary,Alan R Morrison

Scientific reports 11:18237 PubMed34521919

2021

KCTD15 deregulation is associated with alterations of the NF-κB signaling in both pathological and physiological model systems.

Applications

Unspecified application

Species

Unspecified reactive species

Giovanni Smaldone,Luigi Coppola,Katia Pane,Monica Franzese,Giuliana Beneduce,Rosanna Parasole,Giuseppe Menna,Luigi Vitagliano,Marco Salvatore,Peppino Mirabelli

Journal of cellular and molecular medicine 25:6773-6785 PubMed34114342

2021

Pro-inflammatory signals induce 20α-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal.

Applications

Unspecified application

Species

Unspecified reactive species

Lubna Nadeem,Rathesh Balendran,Anna Dorogin,Sam Mesiano,Oksana Shynlova,Stephen J Lye

Cell death & disease 11:1004 PubMed33230105

2020

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara R Battaglia,Silvia Cursano,Enrico Calzia,Alberto Catanese,Tobias M Boeckers

Molecular psychiatry : PubMed32051550

2020

A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Cursano,Chiara R Battaglia,Carolina Urrutia-Ruiz,Stefanie Grabrucker,Michael Schön,Jürgen Bockmann,Sonja Braumüller,Peter Radermacher,Francesco Roselli,Markus Huber-Lang,Tobias M Boeckers

PloS one 14:e0225066 PubMed31703091

2019

Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Minori Kubota,Kazuki Kakimoto,Takatoshi Nakagawa,Eiko Koubayashi,Kei Nakazawa,Hideki Tawa,Yuki Hirata,Toshihiko Okada,Ken Kawakami,Akira Asai,Shuhei Hosomi,Toshihisa Takeuchi,Shinya Fukunishi,Takuya Inoue,Michio Asahi,Kazuhide Higuchi

Cells 8: PubMed31510045

2019

An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Gastón Barbero,María Victoria Castro,María Belén Villanueva,María Josefina Quezada,Natalia Brenda Fernández,Sharon DeMorrow,Pablo Lopez-Bergami
View all publications
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