JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB273390

JTE 607 dihydrochloride

Be the first to review this product! Submit a review

|

(0 Publication)

MW 597.4 Da, Purity >98%. Inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC's), e.g. IC50's = 11 nM (TNF-α), 5.9 nM (IL-1β), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10). Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
1 Images
Chemical Structure - JTE 607 dihydrochloride (AB273390)
  • Chemical Structure

Lab

Chemical Structure - JTE 607 dihydrochloride (AB273390)

Chemical structure of JTE 607 dihydrochloride, 188791-09-5

Key facts

CAS number

188791-09-5

Purity

>98%

Form

Solid

form

Molecular weight

597.4 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>3</sub><sub>3</sub>Cl<sub>4</sub>N<sub>3</sub>O<sub>5</sub>

PubChem

9938544

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in water to 100 mM

Biochemical name

JTE 607 dihydrochloride

Biological description

Inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC's), e.g. IC50's = 11 nM (TNF-α), 5.9 nM (IL-1β), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10). Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

Canonical smiles

CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(C(=C2O)Cl)OCCN3CCN(CC3)C)Cl.Cl.Cl

Isomeric smiles

CCOC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=CC(=C(C(=C2O)Cl)OCCN3CCN(CC3)C)Cl.Cl.Cl

InChi

InChI=1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1

InChiKey

JUJAUEQJEWIWCQ-FJSYBICCSA-N

IUPAC Name

ethyl (2S)-2-[[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate;dihydrochloride

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB120728

trans-Retinoic acid, Stem cell differentiator

Immunocytochemistry/ Immunofluorescence - trans-Retinoic acid, Stem cell differentiator (AB120728)

  • 0
  • 0
Biochemicals

AB141115

scyllo-Inositol, Endogenous inositol isomer

Chemical Structure - scyllo-Inositol, Endogenous inositol isomer (AB141115)

  • 0
  • 0
Biochemicals

AB120078

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

  • 0
  • 0
Biochemicals

AB146203

pNPP-Na hexahydrate, Alkaline phosphatase substrate

Chemical Structure - pNPP-Na hexahydrate, Alkaline phosphatase substrate (AB146203)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com