K02288

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MW 352.4 Da, Purity >98%. A potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling.

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AAT 5, ACTR-I, ACVR1A, ACVR1_HUMAN, ACVRLK 4, ACVRLK2, ALK-2, ALK-5, Activin A receptor type I, Activin A receptor type II like kinase, Activin A receptor type II like kinase 2, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin receptor type I, Activin receptor type-1, Activin receptor-like kinase 2, Activin receptor-like kinase 5, BMP1_HUMAN, Bone morphogenetic protein 1, FOP, Hydroxyalkyl protein kinase, LDS1A, LDS2A, MSSE, Mammalian tolloid protein, OI13, PCOLC, PCP2, Procollagen C endopeptidase, Procollagen C proteinase, Procollagen C-proteinase, SKR 4, SKR1, Serine/threonine-protein kinase receptor R1, Serine/threonine-protein kinase receptor R4, TGF-B superfamily receptor type I, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TLD, TSR-I, TbetaR-I, Tolloid, Drosophila, homolog of, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor-beta receptor type I, activin A receptor type II-like protein kinase of 53kD, mTld