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AB120419

K252a, protein and CAM kinase inhibitor

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(4 Publications)

MW 467.5 Da, Purity >99%. Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC50 = 18-25 nM), Serine/threonine protein kinases (IC50 values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.
1 Images
Chemical Structure - K252a, protein and CAM kinase inhibitor (AB120419)
  • Chemical Structure

Lab

Chemical Structure - K252a, protein and CAM kinase inhibitor (AB120419)

2D chemical structure image of ab120419, K252a, protein and CAM kinase inhibitor

Key facts

CAS number

99533-80-9

Purity

>99%

Form

Solid

form

Source

Nocardiopsis sp.

Molecular weight

467.5 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>2</sub><sub>1</sub>N<sub>3</sub>O<sub>5</sub>

PubChem

3035817

Nature

Native

Solubility

Soluble in DMSO to 25 mM

Soluble in ethanol to 5 mM

Biochemical name

Antibiotic K 252a

Biological description

Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC50 = 18-25 nM), Serine/threonine protein kinases (IC50 values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.

Canonical smiles

CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

Isomeric smiles

C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

InChi

InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChiKey

KOZFSFOOLUUIGY-SOLYNIJKSA-N

IUPAC Name

methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate

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Complementary Products

Biochemicals

AB144414

Gouml 6983, PKC inhibitor

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Primary Antibodies

AB183218

Anti-TNF alpha antibody [EPR19147]

20ul selling size|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-TNF alpha antibody [EPR19147] (AB183218)

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Biochemicals

AB146196

ANA-12, TrkB antagonist

Chemical Structure - ANA-12, TrkB antagonist (AB146196)

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Biochemicals

AB120297

Phorbol 12-myristate 13-acetate (PMA), PKC activator

Chemical Structure - Phorbol 12-myristate 13-acetate (PMA), PKC activator (AB120297)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer gene therapy 31:1357-1379 PubMed39039193

2024

Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.

Applications

Unspecified application

Species

Unspecified reactive species

Rohini Gupta,Melanie Dittmeier,Gisela Wohlleben,Vera Nickl,Thorsten Bischler,Vanessa Luzak,Vanessa Wegat,Dennis Doll,Annemarie Sodmann,Elena Bady,Georg Langlhofer,Britta Wachter,Steven Havlicek,Jahnve Gupta,Evi Horn,Patrick Lüningschrör,Carmen Villmann,Bülent Polat,Jörg Wischhusen,Camelia M Monoranu,Jochen Kuper,Robert Blum

Nature communications 13:4820 PubMed35973996

2022

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Xiong,Jianming Liao,Xia Liu,Zhaohui Zhang,Jonathan Adams,Roberto Pacifici,Keqiang Ye

Glia 66:1395-1416 PubMed29473218

2018

NGF steers microglia toward a neuroprotective phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Caterina Rizzi,Alexia Tiberi,Michela Giustizieri,Maria Cristina Marrone,Francesco Gobbo,Nicola Maria Carucci,Giovanni Meli,Ivan Arisi,Mara D'Onofrio,Silvia Marinelli,Simona Capsoni,Antonino Cattaneo

Nano letters 16:3989-94 PubMed27266855

2016

Direct Tracking of Amyloid and Tu Dynamics in Neuroblastoma Cells Using Nanoplasmonic Fiber Tip Probes.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Liang,Yiying Zhang,Wooyoung Hong,Yuanlin Dong,Zhongcong Xie,Qimin Quan
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