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MW 213.23 Da, Purity >99%. Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.

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Images

Chemical Structure - Kainic acid (mM/ml), Prototypic kainate receptor agonist (AB144490), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Kainic acid (mM/ml), Prototypic kainate receptor agonist (AB144490), expandable thumbnail

Publications

Key facts

CAS number
487-79-6
Purity
> 99%
Form
Solid
Source
Digenea simplex
Molecular weight
213.23 Da
Molecular formula
C10H15NO4
PubChem identifier
10255
Nature
Native

Target data

Alternative names

AMPA 1, AMPA-selective glutamate receptor 1, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243

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MW 213.23 Da, Purity >99%. Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.

Key facts

Purity
> 99%
Source
Digenea simplex
PubChem identifier
10255
Biochemical name
Kainic acid
Biological description

Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.

Canonical SMILES
CC(=C)C1CNC(C1CC(=O)O)C(=O)O
Isomeric SMILES
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
InChI
InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChIKey
VLSMHEGGTFMBBZ-OOZYFLPDSA-N
IUPAC name
(2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Kainic acid (mM/ml), Prototypic kainate receptor agonist (ab144490), expandable thumbnail

    Chemical Structure - Kainic acid (mM/ml), Prototypic kainate receptor agonist (ab144490)

    2D chemical structure image of ab144490, Kainic acid (mM/ml), Prototypic kainate receptor agonist

  • Immunocytochemistry/ Immunofluorescence - Kainic acid (mM/ml), Prototypic kainate receptor agonist (ab144490), expandable thumbnail
    Image from Menteyne, A et al., PloS one., 4(8): e6770. Fig 1A.; doi: 10.1371/journal.pone.0006770 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Immunocytochemistry/ Immunofluorescence - Kainic acid (mM/ml), Prototypic kainate receptor agonist (ab144490)

    Immunocytochemistry/ Immunofluorescence analysis of microglial cells in the stratum radiatum of the CA1 region of the hippocampus of CX3CR1egfp/+ mice in control conditions (left) or 48 hours after status epilepticus (SE) induced by intra-peritoneal injection of kainate (right). Each image is a maximum intensity z-projection of 31 confocal slices for a total thickness of 12 μm.

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