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AB144490

Kainic acid (mM/ml), Prototypic kainate receptor agonist

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(37 Publications)

MW 213.23 Da, Purity >99%. Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.
2 Images
Immunocytochemistry/ Immunofluorescence - Kainic acid (mM/ml), Prototypic kainate receptor agonist (AB144490)
  • ICC/IF

PubMed

Immunocytochemistry/ Immunofluorescence - Kainic acid (mM/ml), Prototypic kainate receptor agonist (AB144490)

Immunocytochemistry/ Immunofluorescence analysis of microglial cells in the stratum radiatum of the CA1 region of the hippocampus of CX3CR1egfp/+ mice in control conditions (left) or 48 hours after status epilepticus (SE) induced by intra-peritoneal injection of kainate (right). Each image is a maximum intensity z-projection of 31 confocal slices for a total thickness of 12 μm.

Image from Menteyne, A et al., PloS one., 4(8): e6770. Fig 1A.; doi: 10.1371/journal.pone.0006770 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - Kainic acid (mM/ml), Prototypic kainate receptor agonist (AB144490)
  • Chemical Structure

Lab

Chemical Structure - Kainic acid (mM/ml), Prototypic kainate receptor agonist (AB144490)

2D chemical structure image of ab144490, Kainic acid (mM/ml), Prototypic kainate receptor agonist

Key facts

CAS number

487-79-6

Purity

>99%

Form

Solid

form

Source

Digenea simplex

Molecular weight

213.23 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>5</sub>NO<sub>4</sub>

PubChem

10255

Nature

Native

Biochemical name

Kainic acid

Biological description

Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.

Canonical smiles

CC(=C)C1CNC(C1CC(=O)O)C(=O)O

Isomeric smiles

CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O

InChi

InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChiKey

VLSMHEGGTFMBBZ-OOZYFLPDSA-N

IUPAC Name

(2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid

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Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

  • 0
  • 0
Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

  • 5
  • 49
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB263899

Anti-NLRP3 antibody [EPR23094-1]

KO Validated|RabMAb|Recombinant

Western blot - Anti-NLRP3 antibody [EPR23094-1] (AB263899)

  • 4
  • 2
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (37)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular neuroscience 18:1366098 PubMed38644975

2024

Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Vibeke Devold Valderhaug,Ola Huse Ramstad,Rosanne van de Wijdeven,Kristine Heiney,Stefano Nichele,Axel Sandvig,Ioanna Sandvig

Hearing research 441:108927 PubMed38096707

2023

Normal behavioral discrimination of envelope statistics in budgerigars with kainate-induced cochlear synaptopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Kenneth S Henry,Anna A Guo,Kristina S Abrams

Neuroimmunomodulation 30:325-337 PubMed37926077

2023

Inhibition of Galectin-3 in a Rat Model of Epilepsy and Kainate-Activated BV2 Cells Limits Microglial Activation Through the NLRP3/Pyroptosis Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Sun,Ying Hao,Chunxiang Li,Yuanyuan Zhao,Haishao Yu,Lin Wang

Journal of visualized experiments : JoVE : PubMed34515684

2021

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Arens Taga,Christa W Habela,Alexandra Johns,Shiyu Liu,Mollie O'Brien,Nicholas J Maragakis

The Journal of neuroscience : the official journal of the Society for Neuroscience 41:118-129 PubMed33177067

2020

Normal Tone-In-Noise Sensitivity in Trained Budgerigars despite Substantial Auditory-Nerve Injury: No Evidence of Hidden Hearing Loss.

Applications

Unspecified application

Species

Unspecified reactive species

Kenneth S Henry,Kristina S Abrams

The Journal of biological chemistry 294:10194-10210 PubMed31092554

2019

The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for mRNA processing.

Applications

Unspecified application

Species

Unspecified reactive species

Maeve Tischbein,Desiree M Baron,Yen-Chen Lin,Katherine V Gall,John E Landers,Claudia Fallini,Daryl A Bosco

Hearing research 374:24-34 PubMed30703625

2019

Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie J Wong,Kristina S Abrams,Kassidy N Amburgey,Yingxuan Wang,Kenneth S Henry

Frontiers in molecular neuroscience 11:5 PubMed29416502

2018

Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Cai Shi,Jia Zeng,Zixi Li,Qingjie Chen,Weijian Hang,Liangtao Xia,Yue Wu,Juan Chen,Anbing Shi

Experimental neurology 247:91-100 PubMed23578819

2013

Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Janin Lautenschläger,Tino Prell,Julia Ruhmer,Lisa Weidemann,Otto W Witte,Julian Grosskreutz

Nature neuroscience 16:632-8 PubMed23542690

2013

Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.

Applications

Unspecified application

Species

Unspecified reactive species

Roland Bock,J Hoon Shin,Alanna R Kaplan,Alice Dobi,Eric Markey,Paul F Kramer,Christina M Gremel,Christine H Christensen,Martin F Adrover,Veronica A Alvarez
View all publications
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