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AB120100

Kainic acid, prototypic kainate receptor agonist

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(79 Publications)

Kainic acid (CAS: 487-79-6)(ab120100) is a prototypic agonist of kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. Kainate receptor (KAR) agonist. MW 213.23.

- Proven performance: cited in over 75 publications
- Available in different sizes to fit your experimental needs. Larger volume format available upon request

Key facts

CAS number

487-79-6

Purity

>99%

Form

Solid

form

Source

Digenea simplex

Molecular weight

213.23 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>5</sub>NO<sub>4</sub>

PubChem

10255

Nature

Native

Biochemical name

Kainic acid

Biological description

Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.

Canonical smiles

CC(=C)C1CNC(C1CC(=O)O)C(=O)O

Isomeric smiles

CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O

InChi

InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChiKey

VLSMHEGGTFMBBZ-OOZYFLPDSA-N

IUPAC Name

(2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid

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Complementary Products

Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

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Biochemicals

AB120315

Picrotoxin, GABAA antagonist

Chemical Structure - Picrotoxin, GABAA antagonist (AB120315)

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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Biochemicals

AB120045

NBQX, AMPA / kainate antagonist

Functional Studies - NBQX, AMPA / kainate antagonist (AB120045)

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Product details

Check out our range of AMPA / kainate antagonist here
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dysfunction in GluR1 and associated AMPA receptors has been implicated in conditions like Alzheimer's disease and epilepsy. Alzheimer's disease exhibits decreased synaptic transmission and plasticity linked to impaired GluR1 function and its interactions with NMDA receptors. In epilepsy abnormal GluR1 activity may contribute to heightened neuronal excitability and seizure propagation. Targeting GluR1 or associated pathways offers potential for therapeutic interventions in these disorders possibly through drugs such as memantine and NBQX which modulate receptor activity.
Pathways

The GluR1-containing AMPA receptors participate significantly in the glutamatergic signaling pathway which is vital for fast excitatory synaptic transmission in the brain. This pathway also involves the NMDA receptors which work together with AMPA receptors to regulate synaptic plasticity and neuronal communication. Additionally the GluR1 interacts within the long-term potentiation (LTP) pathway contributing to the strengthening of synapses an essential mechanism underlying learning and memory.

Biological function summary

The GluR1 subunit is an essential component of the AMPA receptor complex which typically forms as a tetramer. This complex modulates synaptic strength and plasticity processes critical for learning and memory. The activity of AMPA receptors including those containing GluR1 is regulated by several auxiliary proteins and is essential for post-synaptic responses. The GluR1 subunit also interacts with other proteins such as TARPs which modulate its trafficking and channel properties.

Glutamate Receptor 1 (AMPA subtype) also known as GluR1 is a subunit of the AMPA receptor complex which mediates fast synaptic transmission in the central nervous system. It is an ionotropic receptor for glutamate functioning by opening ion channels to allow the flow of Na+ and Ca2+ ions across the cell membrane contributing to excitatory neurotransmission. The GluR1 subunit has a molecular mass of approximately 100 kDa. This receptor is commonly expressed in the brain regions such as the hippocampus and the cerebral cortex playing an important role in synaptic plasticity and memory formation.
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Product protocols

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Publications (79)

Recent publications for all applications. Explore the full list and refine your search

Acta physiologica (Oxford, England) 241:e70031 PubMed40165367

2025

Neuronal activity modulates the expression of secretagogin, a Ca sensor protein, during mammalian forebrain development.

Applications

Unspecified application

Species

Unspecified reactive species

János Hanics,Evgenii O Tretiakov,Roman A Romanov,Anna Gáspárdy,Zsófia Hevesi,Robert Schnell,Tibor Harkany,Alán Alpár

Epilepsia 66:1703-1717 PubMed39932393

2025

One-hertz low-frequency stimulation of anterior substantia nigra pars reticulata attenuates seizure via biased disinhibitory circuits.

Applications

Unspecified application

Species

Unspecified reactive species

Dongxiao Jiang,Lin Yang,Lilong Yu,Mengdi Zhang,Yuan Zhou,Yi Wang,Yeping Ruan,Fan Fei,Zhong Chen

CNS neuroscience & therapeutics 31:e70265 PubMed39924980

2025

Low-Frequency Stimulation at the Ventromedial Hypothalamus Exhibits Broad-Spectrum Efficacy Across Models of Epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Shuang Zou,Yiwei Gong,Mengqi Yan,Zhijian Yuan,Minjuan Sun,Shuo Zhang,Yuanzhi Yang,Xiongfeng Guo,Lan Huang,Fan Fei,Yi Wang,Zhong Chen,Cenglin Xu

F1000Research 12:47 PubMed39816762

2025

Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to  organotypic hippocampal slice culture.

Applications

Unspecified application

Species

Unspecified reactive species

Machlusil Husna,Kusworini Handono,Hidayat Sujuti,Aulanni'am Aulanni'am,Ettie Rukmigarsari

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2407525 PubMed39476381

2024

Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Hui Sun,Bo-Wu Hu,Li-Heng Tan,Lin Lin,Shu-Xia Cao,Tan-Xia Wu,Hao Wang,Bin Yu,Qin Wang,Hong Lian,Jiadong Chen,Xiao-Ming Li

Gene therapy 32:106-120 PubMed39455855

2024

Chemogenetics with PSAM-GlyR decreases excitability and epileptiform activity in epileptic hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Gonzalez-Ramos,Fredrik Berglind,Jan Kudláček,Elza R Rocha,Esbjörn Melin,Ana M Sebastião,Cláudia A Valente,Marco Ledri,My Andersson,Merab Kokaia

Biomarker research 12:103 PubMed39272194

2024

Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Quanlei Liu,Chunhao Shen,Yang Dai,Ting Tang,Changkai Hou,Hongyi Yang,Yihe Wang,Jinkun Xu,Yongchang Lu,Yunming Wang,Yongzhi Shan,Penghu Wei,Guoguang Zhao

Epilepsia open 9:1445-1457 PubMed38831626

2024

Septal stimulation attenuates hippocampal seizure with subregion specificity.

Applications

Unspecified application

Species

Unspecified reactive species

Qingyang Zhang,Yu Wang,Fei Wang,Dongxiao Jiang,Yingjie Song,Lin Yang,Mengdi Zhang,Yi Wang,Yeping Ruan,Jiajia Fang,Fan Fei

eNeuro 11: PubMed38641413

2024

Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Alicia M Hall,Noriko Kamei,Manlin Shao,Hyun-Seung Mun,Kevin Chen,Yuncai Chen,Tallie Z Baram

Communications biology 6:1029 PubMed37821582

2023

Slack K channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing.

Applications

Unspecified application

Species

Unspecified reactive species

David Skrabak,Helmut Bischof,Thomas Pham,Peter Ruth,Rebekka Ehinger,Lucas Matt,Robert Lukowski
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