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AB141180

Kartogenin, stem cell differentiation

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MW 317.3 Da, Purity >98%. Promotes differentiation of human mesenchymal stems cells into chondrocytes (EC50 = 100 nM). Partially supresses release of nitric oxide. Active in vivo and cell permeable.

View Alternative Names

Abacavir hypersensitivity, susceptibility to, Beta-interferon, Drug-induced liver injury due to flucloxacillin, Fibroblast interferon, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, Lymphocyte antigen, MGC96956, MHC class I antigen B 7, Major Histocompatibility Complex Class I B, Synovitis, chronic, susceptibility to, leukocyte antigen class I-B

1 Images
Chemical Structure - Kartogenin, stem cell differentiation (AB141180)
  • Chemical Structure

Lab

Chemical Structure - Kartogenin, stem cell differentiation (AB141180)

2D chemical structure image of ab141180, Kartogenin, stem cell differentiation

Key facts

CAS number

4727-31-5

Purity

>98%

Form

Solid

form

Molecular weight

317.3 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>5</sub>NO<sub>3</sub>

PubChem

2826191

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

Kartogenin

Biological description

Promotes differentiation of human mesenchymal stems cells into chondrocytes (EC50 = 100 nM). Partially supresses release of nitric oxide. Active in vivo and cell permeable.

Canonical smiles

C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3C(=O)O

InChi

InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)

InChiKey

SLUINPGXGFUMLL-UHFFFAOYSA-N

IUPAC Name

2-[(4-phenylphenyl)carbamoyl]benzoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon beta (IFN-β) also known as IFNB1 is a cytokine widely recognized in the immune system for its role in antiviral defense. It has a molecular mass of about 20-25 kDa. IFN-β is mainly produced by fibroblasts and some macrophages. Its expression increases in response to viral infections as well as other external stimuli like double-stranded RNA. The regulation of IFN-β expression involves intricate interactions with various transcription factors and it mediates its effects by binding to specific receptors on the cell surface initiating JAK-STAT signaling pathway.
Biological function summary

This protein helps modulate the immune response by enhancing the activity of immune cells such as natural killer (NK) cells and promoting the presentation of antigens through major histocompatibility complex (MHC) class I molecules. IFN-β plays a significant role in the immune system's ability to recognize and respond to pathogens. It functions in a complex involving multiple signaling pathways that communicate cellular stress and activate immune defense mechanisms. Through its impact on gene expression IFN-β can modulate key cellular processes that contain pathogen spread.

Pathways

The signaling of IFN-β integrates with essential immune pathways like the JAK-STAT and the MAPK pathways. The JAK-STAT pathway an important signaling mechanism allows cells to respond to extracellular proteins and manage immune response. IFN-β interaction with LAT and STAT1 emphasizes its role in amplifying antiviral states in cells. Additionally IFN-β can influence MAPK pathway components thereby impacting cell survival proliferation and differentiation during immune challenges.

IFN-β associates with multiple sclerosis and persistent viral infections. Its therapeutic use in multiple sclerosis highlights its capacity to reduce the frequency of exacerbations and control neuroinflammation. IFN-β administration also impacts hepatitis C virus burden exhibiting its role in chronic infection management. Its interplay with other cytokines such as interleukin (IL)-10 and tumor necrosis factor (TNF) supports its therapeutic relevance in managing these conditions and substantiates its application in clinical therapies.
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Product protocols

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