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AB120132

Ketanserin tartrate, 5-HT2 antagonist

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MW 545.5 Da, Purity >98%. 5-HT2A antagonist. Also shows moderate affinity and selectivity for human 5-HT1Dα over 5-HT1β, and affinity at α1 adrenoceptors. Antihypertensive *in vivo*.

View Alternative Names

15-PGDH, 15-hydroxyprostaglandin dehydrogenase [NAD+], ASRT2, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, G protein coupled receptor 154, G protein coupled receptor PGR14, G protein coupled receptor for asthma susceptibility, GPR 154, GPRA, H-ERG, Hpgd, Hydroxyprostaglandin dehydrogenase 15 (NAD), KCNH2_HUMAN, Kv11.1, LQT 2, MVTR, NAD+ dependent 15 hydroxyprostaglandin dehydrogenase, NPSR, Neuropeptide S receptor, Neuropeptide S receptor 1, OTTHUMP00000218960, OTTHUMP00000219016, OTTHUMP00000219018, PGDH1, PGDH_HUMAN, PGR 14, PHOAR1, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Prostaglandin dehydrogenase 1, SDR36C1, SQT1, Short chain dehydrogenase/reductase family 36C member 1, VRR 1, Vasopressin receptor related receptor 1, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, eag homolog, hERG-1, nps receptor

1 Images
Chemical Structure - Ketanserin tartrate, 5-HT2 antagonist (AB120132)
  • Chemical Structure

Lab

Chemical Structure - Ketanserin tartrate, 5-HT2 antagonist (AB120132)

2D chemical structure image of ab120132, Ketanserin tartrate, 5-HT2 antagonist

Key facts

CAS number

83846-83-7

Purity

>98%

Form

Solid

form

Molecular weight

545.5 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>8</sub>FN<sub>3</sub>O<sub>9</sub>

PubChem

135348

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in water to 10 mM

Biochemical name

Ketanserin tartrate

Biological description

5-HT2A antagonist. Also shows moderate affinity and selectivity for human 5-HT1Dα over 5-HT1β, and affinity at α1 adrenoceptors. Antihypertensive *in vivo*.

Canonical smiles

C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O.C(C(C(=O)O)O)(C(=O)O)O

InChi

InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)

InChiKey

KMTLTEVOQLMYRS-UHFFFAOYSA-N

IUPAC Name

2,3-dihydroxybutanedioic acid;3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target '15-PGDH H-ERG NPSR1' refers to three different proteins that serve distinct functions. 15-PGDH the enzyme 15-hydroxyprostaglandin dehydrogenase plays a role in the catabolism of prostaglandins and has a mass of approximately 29 kDa. It expresses highly in the liver placenta lungs and kidneys. H-ERG or human ether à-go-go-related gene potassium channel is a protein contributing to the cardiac action potential and has a molecular mass of about 134 kDa. It is expressed in the heart and nervous system. NPSR1 known as the Neuropeptide S receptor is a G-protein coupled receptor predominantly located in the central nervous system and the respiratory tract.
Biological function summary

These proteins serve various essential functions. 15-PGDH is responsible for regulating prostaglandin levels which modulate inflammation and cellular differentiation. H-ERG forms the pore of potassium ion channels critical for electrical signaling in the heart therefore preventing arrhythmias. NPSR1 involves signaling related to neuropeptides influencing anxiety and asthma responses. These proteins do not function as part of a single complex but perform distinct roles important for maintaining homeostasis within their respective systems.

Pathways

The protein 15-PGDH functions primarily in the eicosanoid signaling pathway impacting inflammatory responses. It associates with enzymes like cyclooxygenase involved in prostaglandin biosynthesis. H-ERG is part of the cardiac electrical signaling pathway interacting with other ion channels to maintain the heart's rhythmic heartbeat. NPSR1 links to neuropeptide signaling pathways modulating intracellular processes through interactions with proteins like G-protein subunits.

These proteins are linked to specific health issues. 15-PGDH's dysregulation associates with cancer due to its role in controlling anti-inflammatory responses. Alterations in H-ERG can lead to cardiac disorders such as Long QT syndrome an irregular heartbeat condition. In this context it interacts with proteins such as KCNQ1 another cardiac channel protein. Meanwhile imbalances in NPSR1 expression connect with asthma influencing airway responses through interaction with other inflammatory mediators.
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Product protocols

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