JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120620

Ketoconazole, cytochrome P450 inhibitor

Be the first to review this product! Submit a review

|

(1 Publication)

MW 531.4 Da, Purity >99%. Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.
1 Images
Chemical Structure - Ketoconazole, cytochrome P450 inhibitor (AB120620)
  • Chemical Structure

Lab

Chemical Structure - Ketoconazole, cytochrome P450 inhibitor (AB120620)

2D chemical structure image of ab120620, Ketoconazole, cytochrome P450 inhibitor

Key facts

CAS number

65277-42-1

Purity

>99%

Form

Solid

form

Molecular weight

531.4 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>8</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

456201

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Soluble in ethanol to 50 mM

Biochemical name

Xolegel

Biological description

Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.

Canonical smiles

CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Isomeric smiles

CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

InChi

InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1

InChiKey

XMAYWYJOQHXEEK-OZXSUGGESA-N

IUPAC Name

1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

style
left-column

Complementary Products

Biochemicals

AB144783

N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin

Chemical Structure - N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin (AB144783)

  • 0
  • 0
Biochemicals

AB120816

Itraconazole, Cytochrome p450 inhibitor

Functional Studies - Itraconazole, Cytochrome p450 inhibitor (AB120816)

  • 0
  • 0
Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7
Proteins & Peptides

AB128447

Recombinant Human UBE2M/UBC12 protein

SDS-PAGE - Recombinant Human UBE2M/UBC12 protein (AB128447)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 9:239 PubMed29445159

2018

Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Muhymin Islam,Roman Mezencev,Brynn McFarland,Hannah Brink,Betsy Campbell,Bushra Tasadduq,Edmund K Waller,Wilbur Lam,Alexander Alexeev,Todd Sulchek
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com