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MW 531.4 Da, Purity >99%. Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.

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Images

Chemical Structure - Ketoconazole, cytochrome P450 inhibitor (AB120620), expandable thumbnail

Publications

Key facts

CAS number
65277-42-1
Purity
> 99%
Form
Solid
Molecular weight
531.4 Da
Molecular formula
C26H28Cl2N4O4
PubChem identifier
456201
Nature
Synthetic

Alternative names

Recommended products

MW 531.4 Da, Purity >99%. Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.

Key facts

Purity
> 99%
PubChem identifier
456201
Solubility

Soluble in DMSO to 75 mM.

Soluble in ethanol to 50 mM.

Biochemical name
Xolegel
Biological description

Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.

Canonical SMILES
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
Isomeric SMILES
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
InChIKey
XMAYWYJOQHXEEK-OZXSUGGESA-N
IUPAC name
1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Ketoconazole, cytochrome P450 inhibitor (ab120620), expandable thumbnail

    Chemical Structure - Ketoconazole, cytochrome P450 inhibitor (ab120620)

    2D chemical structure image of ab120620, Ketoconazole, cytochrome P450 inhibitor

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Product protocols

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