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MW 469.4 Da, Purity >99%. Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo. .

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Images

Chemical Structure - Ki 8751 (AB141266), expandable thumbnail

Key facts

CAS number
228559-41-9
Purity
> 99%
Form
Solid
Molecular weight
469.4 Da
Molecular formula
C24H18F3N3O4
PubChem identifier
11317348
Nature
Synthetic

Target data

Recommended products

MW 469.4 Da, Purity >99%. Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo. .

Key facts

Purity
> 99%
PubChem identifier
11317348
Solubility

≥23.45mg/mL in DMSO.

Biochemical name
1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea
Biological description

Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo.

Canonical SMILES
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F
InChI
InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
InChIKey
LFKQSJNCVRGFCC-UHFFFAOYSA-N
IUPAC name
1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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1 product image

  • Chemical Structure - Ki 8751 (ab141266), expandable thumbnail

    Chemical Structure - Ki 8751 (ab141266)

    Chemical structure of Ki 8751, 228559-41-9

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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