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AB141266

Ki 8751

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MW 469.4 Da, Purity >99%. Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo. .
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Chemical Structure - Ki 8751 (AB141266)
  • Chemical Structure

Lab

Chemical Structure - Ki 8751 (AB141266)

Chemical structure of Ki 8751, 228559-41-9

Key facts

CAS number

228559-41-9

Purity

>99%

Form

Solid

form

Molecular weight

469.4 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>1</sub><sub>8</sub>F<sub>3</sub>N<sub>3</sub>O<sub>4</sub>

PubChem

11317348

Nature

Synthetic

Solubility

≥23.45mg/mL in DMSO

Biochemical name

1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea

Biological description

Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo.

Canonical smiles

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F

InChi

InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)

InChiKey

LFKQSJNCVRGFCC-UHFFFAOYSA-N

IUPAC Name

1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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