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MW 518.5 Da, Purity >=98%. An ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 μM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.

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Publications

Key facts

CAS number
1589527-65-0
Purity
>= 98%
Form
Solid
Molecular weight
518.5 Da
Molecular formula
C28H25F3N6O
PubChem identifier
73425700
Nature
Synthetic

Target data

Recommended products

MW 518.5 Da, Purity >=98%. An ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 μM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.

Key facts

Purity
>= 98%
PubChem identifier
73425700
Solubility

~20 mg/ml in DMSO.

Biochemical name
1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea
Biological description

An ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 μM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.

Canonical SMILES
CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
InChI
InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)
InChIKey
NOHQEAFAESMMDX-UHFFFAOYSA-N
IUPAC name
1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea

Storage

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B2594 KIRA6. B2594-5 is the same size as the 5 mg size of ab287101.

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