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AB120181

Kisspeptin-13 (4-13) (human) (KiSS-1 (112-121)), AXOR12 agonist

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MW 1302.4 Da, Purity >95%. Achieve your results faster with highly validated, pure and trusted compounds.
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Chemical Structure - Kisspeptin-13 (4-13) (human) (KiSS-1 (112-121)), AXOR12 agonist (AB120181)
  • Chemical Structure

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Chemical Structure - Kisspeptin-13 (4-13) (human) (KiSS-1 (112-121)), AXOR12 agonist (AB120181)

2D chemical structure image of ab120181, Kisspeptin-13 (4-13) (human) (KiSS-1 (112-121)), AXOR12 agonist

Key facts

CAS number

374675-21-5

Purity

>95%

Form

Solid

form

Molecular weight

1302.4 Da

Molecular formula

C<sub>6</sub><sub>3</sub>H<sub>8</sub><sub>3</sub>N<sub>1</sub><sub>7</sub>O<sub>1</sub><sub>4</sub>

PubChem

25240297

Nature

Synthetic

Solubility

Soluble in water

Biochemical name

Kisspeptin-10

Canonical smiles

CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC(=O)N)NC(=O)C(CC5=CC=C(C=C5)O)N

Isomeric smiles

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)N

InChi

InChI=1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)/t41-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1

InChiKey

RITKWYDZSSQNJI-INXYWQKQSA-N

IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]butanediamide

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Complementary Products

Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB177203

Anti-MKRN3 antibody

Western blot - Anti-MKRN3 antibody (AB177203)

  • 0
  • 0
Secondary Antibodies

AB172329

Rat monoclonal [SB76b] Anti-Mouse IgG3 gamma chain (Alexa Fluor® 647)

Flow Cytometry - Rat monoclonal [SB76b] Anti-Mouse IgG3 gamma chain (Alexa Fluor® 647) (AB172329)

  • 0
  • 0
Multiplex Kits

AB201111

Protease Inhibitor Cocktail (EDTA-free)

  • 5
  • 1
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NPFF1 receptor NPFF2 receptor and GPR54 also known as the Kisspeptin receptor belong to the G protein-coupled receptor family. These receptors mechanically function by binding to neuropeptides such as neuropeptide FF and Kisspeptin resulting in signal transduction that affects various cellular responses. GPR54 the Kisspeptin receptor has a molecular mass of about 42 to 44 kDa. The NPFF1 and NPFF2 receptors are broadly expressed in the central nervous system while GPR54 is mainly found in the hypothalamus pituitary and reproductive organs.
Biological function summary

These receptors play significant roles in maintaining homeostasis and reproductive functions by mediating major neurophysiological processes. GPR54 coupled with Kisspeptin is part of an important neuroendocrine complex that stimulates the release of gonadotropin-releasing hormone (GnRH) which ultimately regulates fertility. The NPFF receptors modulate pain processing and may influence opioid peptide effects in the brain. These interactions suggest the importance of these receptors in the neuroendocrine and nociceptive systems.

Pathways

NPFF1 and NPFF2 receptors and GPR54 play important roles in neuroendocrine pathways and reproductive hormonal regulation. The Kisspeptin-GPR54 signaling pathway is essential for the hypothalamic-pituitary-gonadal axis influencing reproductive development and function. GPR54 interacting with proteins such as GnRH coordinates the onset of puberty and fertility. This pathway is also integrally linked to energy homeostasis involving proteins like leptin which modulates its activity.

Disruptions in the signaling of these receptors are associated with certain reproductive and neurological conditions. Abnormal GPR54 and Kisspeptin function have been linked to reproductive disorders including hypogonadotropic hypogonadism a condition marked by reduced sexual development. In the context of pain modulation alterations in NPFF receptor signaling have implications in chronic pain disorders. In both cases related proteins such as GnRH and opioids may exhibit dysregulated activity exacerbating these conditions.
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Product protocols

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