KN-93, CaM kinase II inhibitor

Key facts

CAS number

139298-40-1

Purity

>98%

Form

Solid

form

Molecular weight

501 Da

Molecular formula

C₂₆H₂₉ClN₂O₄S

PubChem

5312122

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM (with warming)

Biochemical name

Methoxybenzene-sulfonamide

Biological description

Potent, cell-permeable CaM kinase II inhibitor (IC₅₀ = 370 nM). Potent voltage gated K⁺ channel blocker (IC₅₀ = 307 nM, K_V1.5). Analog of water soluble KN-93 (ab120980). Suppresses early afterdepolarization. Induces ROS generation and apoptosis. Shows central effects in vivo.

Canonical smiles

CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC

Isomeric smiles

CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC

InChi

InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+

InChiKey

LLLQTDSSHZREGW-AATRIKPKSA-N

IUPAC Name

N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide