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MW 599 Da, Purity >99%. Potent, specific and cell-permeable calmodulin-dependent protein kinase (CaMK) II inhibitor (IC50 = 370 nM). Also a potent and direct extracellular open channel voltage-gated potassium channel blocker (IC50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition. Water soluble.

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Images

Chemical Structure - KN-93 (water soluble), CaMK II inhibitor (AB120980), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (AB120980), expandable thumbnail

Publications

Key facts

CAS number
1188890-41-6
Purity
> 99%
Form
Solid
Molecular weight
599 Da
Molecular formula
C26H32ClN2O8PS
PubChem identifier
16760530
Nature
Synthetic

Target data

Recommended products

MW 599 Da, Purity >99%. Potent, specific and cell-permeable calmodulin-dependent protein kinase (CaMK) II inhibitor (IC50 = 370 nM). Also a potent and direct extracellular open channel voltage-gated potassium channel blocker (IC50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition. Water soluble.

Key facts

Purity
> 99%
PubChem identifier
16760530
Solubility

Soluble in water to 100 mM.

Soluble in DMSO to 100 mM.

Biochemical name
KN-93 Phosphate
Biological description

Potent, specific and cell-permeable calmodulin-dependent protein kinase (CaMK) II inhibitor (IC50 = 370 nM). Also a potent and direct extracellular open channel voltage-gated potassium channel blocker (IC50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition. Water soluble.

Canonical SMILES
CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O
Isomeric SMILES
CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O
InChI
InChI=1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+;
InChIKey
NNKJTPOXLIILMB-IPZCTEOASA-N
IUPAC name
N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide;phosphoric acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions

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2 product images

  • Chemical Structure - KN-93 (water soluble), CaMK II inhibitor (ab120980), expandable thumbnail

    Chemical Structure - KN-93 (water soluble), CaMK II inhibitor (ab120980)

    2D chemical structure image of ab120980, KN-93 (water soluble), CaMK II inhibitor

  • Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (ab120980), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (ab120980)

    ab40754 staining cyclin D1 in MCF7 cells treated with KN-93 (water soluble) (ab120980), by ICC/IF. Decrease in cyclin D1 expression correlates with increased concentration of KN-93 (water soluble), as described in literature.
    The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab120980 (KN-93 (water soluble)) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab40754 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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