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AB146198

Ko-143, BCRP inhibitor

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MW 469.6 Da. Potent, selective BCRP inhibitor (EC50 values are 23 and 26 nM respectively for the export of mitoxantrone (ab145668, ab141041) and topotecan (ab120388) in cancer cell lines). Non-toxic fumitremorgin C (ab144258) analog. Shows chemopotentiating effects in vivo. .
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Chemical Structure - Ko-143, BCRP inhibitor (AB146198)
  • Chemical Structure

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Chemical Structure - Ko-143, BCRP inhibitor (AB146198)

2D chemical structure image of ab146198, Ko-143, BCRP inhibitor

Key facts

CAS number

461054-93-3

Form

Solid

form

Molecular weight

469.6 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>3</sub><sub>5</sub>N<sub>3</sub>O<sub>5</sub>

PubChem

10322450

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 50 mM

Biochemical name

tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate

Biological description

Potent, selective BCRP inhibitor (EC50 values are 23 and 26 nM respectively for the export of mitoxantrone (ab145668, ab141041) and topotecan (ab120388) in cancer cell lines). Non-toxic fumitremorgin C (ab144258) analog. Shows chemopotentiating effects in vivo.

Canonical smiles

CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC

Isomeric smiles

CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC

InChi

InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1

InChiKey

NXNRAECHCJZNRF-JBACZVJFSA-N

IUPAC Name

tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate

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Complementary Products

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AB207732

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Secondary Antibodies

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Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

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Biochemicals

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Biochemicals

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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