AB120637

KU-55933, competitive ATM kinase inhibitor

Name: KU-55933, competitive ATM kinase inhibitor (CAS 587871-26-9) | Abcam
Brand: Abcam Limited
SKU: AB120637
Price: 245 USD
Availability: InStock

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(27 Publications)

MW 395.5 Da, Purity >99%. Potent, selective and competitive ATM kinase inhibitor. IC₅₀ values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), >100000 (ATR) and >100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.

2 Images

Functional Studies - KU-55933, competitive ATM kinase inhibitor (AB120637)

FuncS

Unknown

Functional Studies - KU-55933, competitive ATM kinase inhibitor (AB120637)

HepG2 cells were incubated at 37°C for 60 minutes with vehicle control (0 μM) and different concentrations of KU-55933 (ab120637). Decreased expression of Acetyl Coenzyme A Carboxylase (phospho S79) (ab31931) in HepG2 cells correlates with an increase in KU-55933 concentration as described in literature.

Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate) 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab31931 at 1 μg /ml and ab8227 at 1 μg /ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

Chemical Structure - KU-55933, competitive ATM kinase inhibitor (AB120637)

Chemical Structure

Lab

Chemical Structure - KU-55933, competitive ATM kinase inhibitor (AB120637)

2D chemical structure image of ab120637, KU-55933, competitive ATM kinase inhibitor

Key facts

CAS number

587871-26-9

Purity

>99%

Form

Solid

form

Molecular weight

395.5 Da

Molecular formula

C21H17NO3S2

PubChem

5278396

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one

Biological description

Potent, selective and competitive ATM kinase inhibitor. IC₅₀ values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), >100000 (ATR) and >100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.

Canonical smiles

C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

InChi

InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChiKey

XRKYMMUGXMWDAO-UHFFFAOYSA-N

IUPAC Name

2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (27)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2403485 PubMed38803048

2024

USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in Cancer.

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Unspecified application

Species

Unspecified reactive species

Yunhui Li,Lei Li,Xinshu Wang,Fei Zhao,Yuntong Yang,Yujuan Zhou,Jiyuan Zhang,Li Wang,Zeshan Jiang,Yuanyuan Zhang,Yuping Chen,Chenming Wu,Ke Li,Tingting Zhang,Ping Wang,Zhiyong Mao,Weiguo Zhu,Xingzhi Xu,Shikang Liang,Zhenkun Lou,Jian Yuan

Oncogene 43:1900-1916 PubMed38671157

2024

The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia.

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Unspecified application

Species

Unspecified reactive species

Guangming Wang,Wenjun Zhang,Jie Ren,Yu Zeng,Xiuyong Dang,Xiaoxue Tian,Wenlei Yu,Zheng Li,Yuting Ma,Pingping Yang,Jinyuan Lu,Junke Zheng,Bing Lu,Jun Xu,Aibin Liang

Signal transduction and targeted therapy 8:183 PubMed37160887

2023

A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors.

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Unspecified application

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Chao Zhang,Qiang Guo,Lifeng Chen,Zheming Wu,Xiao-Jian Yan,Chengyang Zou,Qiuxue Zhang,Jiahong Tan,Tian Fang,Qunxian Rao,Yang Li,Shizhen Shen,Min Deng,Liewei Wang,Huanyao Gao,Jia Yu,Hu Li,Cheng Zhang,Somaira Nowsheen,Jake Kloeber,Fei Zhao,Ping Yin,Chunbo Teng,Zhongqiu Lin,Kun Song,Shuzhong Yao,Liangqing Yao,Lingying Wu,Yong Zhang,Xiaodong Cheng,Qinglei Gao,Jian Yuan,Zhenkun Lou,Jin-San Zhang

Molecular cell 83:1043-1060.e10 PubMed36854302

2023

SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology.

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Unspecified application

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Jinzhou Huang,Chenming Wu,Jake A Kloeber,Huanyao Gao,Ming Gao,Qian Zhu,Yiming Chang,Fei Zhao,Guijie Guo,Kuntian Luo,Haiming Dai,Sijia Liu,Qiru Huang,Wootae Kim,Qin Zhou,Shouhai Zhu,Zheming Wu,Xinyi Tu,Ping Yin,Min Deng,Liewei Wang,Jian Yuan,Zhenkun Lou

Open biology 11:210221 PubMed34610268

2021

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.

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Unspecified application

Species

Unspecified reactive species

Heeyoun Bunch,Jaehyeon Jeong,Keunsoo Kang,Doo Sin Jo,Anh T Q Cong,Deukyeong Kim,Donguk Kim,Dong-Hyung Cho,You Mie Lee,Benjamin P C Chen,Matthew J Schellenberg,Stuart K Calderwood

Cell reports 36:109383 PubMed34260925

2021

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.

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Shin-Ya Isobe,Shin-Ichiro Hiraga,Koji Nagao,Hiroyuki Sasanuma,Anne D Donaldson,Chikashi Obuse

The EMBO journal 39:e103420 PubMed32935380

2020

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.

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Unspecified application

Species

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Chongkui Sun,Kun Wang,Amanda J Stock,Yi Gong,Tyler G Demarest,Beimeng Yang,Neelam Giri,Lea Harrington,Blanche P Alter,Sharon A Savage,Vilhelm A Bohr,Yie Liu

eLife 9: PubMed32831175

2020

The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation.

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Unspecified application

Species

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Kanji Okumoto,Mahmoud El Shermely,Masanao Natsui,Hidetaka Kosako,Ryuichi Natsuyama,Toshihiro Marutani,Yukio Fujiki

Molecular cell 79:824-835.e5 PubMed32649882

2020

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.

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Unspecified application

Species

Unspecified reactive species

Jinzhou Huang,Qin Zhou,Ming Gao,Somaira Nowsheen,Fei Zhao,Wootae Kim,Qian Zhu,Yusuke Kojima,Ping Yin,Yong Zhang,Guijie Guo,Xinyi Tu,Min Deng,Kuntian Luo,Bo Qin,Yuichi Machida,Zhenkun Lou

Scientific reports 10:4441 PubMed32157166

2020

Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.

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Masahiro Uehara,Tetsuro Kusaba,Tomoharu Ida,Kunihiro Nakai,Tomohiro Nakata,Aya Tomita,Noriko Watanabe-Uehara,Kisho Ikeda,Takashi Kitani,Noriyuki Yamashita,Yuhei Kirita,Satoaki Matoba,Benjamin D Humphreys,Keiichi Tamagaki

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KU-55933, competitive ATM kinase inhibitor

Functional Studies - KU-55933, competitive ATM kinase inhibitor (AB120637)

Chemical Structure - KU-55933, competitive ATM kinase inhibitor (AB120637)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (27)

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Primary Antibodies

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