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AB273596

KW2449

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MW 332.4 Da, Purity >98%. Multi targeted inhibitor of FLT3 ( with an IC50 of 6.6nM), ABL, ABL-T315I, and Aurora kinase. Tumor growth inhibition in FLT3-mutated xenograft model in vitro. Shows a potent and significant antitumor effect in a dose-dependent manner in MOLM-13 tumour xenograft model in vivo..
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Chemical Structure - KW2449 (AB273596)
  • Chemical Structure

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Chemical Structure - KW2449 (AB273596)

Chemical structure of KW2449, 1000669-72-6

Key facts

CAS number

841258-76-2

Purity

>98%

Form

Solid

form

Molecular weight

332.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>0</sub>N<sub>4</sub>O

PubChem

11427553

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone

Biological description

Multi targeted inhibitor of FLT3 ( with an IC50 of 6.6nM), ABL, ABL-T315I, and Aurora kinase. Tumor growth inhibition in FLT3-mutated xenograft model in vitro. Shows a potent and significant antitumor effect in a dose-dependent manner in MOLM-13 tumour xenograft model in vivo.

Canonical smiles

C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43

Isomeric smiles

C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43

InChi

InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+

InChiKey

YYLKKYCXAOBSRM-JXMROGBWSA-N

IUPAC Name

[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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