MW 189.17 Da, Purity >99%. Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective *in vivo*. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256).
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- Communications biology 6:2672023Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMing-Yi Chou,Xuhui Cao,Kuan-Chu Hou,Meng-Han Tsai,Chih-Yu Lee,Meng-Fai Kuo,Vin-Cent Wu,Hsin-Yi Huang,Schahram Akbarian,Sheng-Kai Chang,Chung-Yi Hu,Shu-Wha Lin,Hsien-Sung HuangPubMed 36918719
- The Journal of neuroscience : the official journal of the Society for Neuroscience 40:6133-61452020Developmentally Transient CB1Rs on Cerebellar Afferents Suppress Afferent Input, Downstream Synaptic Excitation, and Signaling to Migrating Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJesse L Barnes,Claudia Mohr,Caitlin R Ritchey,Chloe M Erikson,Hiroko Shiina,David J RossiPubMed 32631938
- Nature communications 8:17762017GABA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl-sensitive WNK1 kinase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMartin Heubl et. al.PubMed 29176664
- Brain : a journal of neurology 139:468-802015Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTakeshi Hiu,Zoya Farzampour,Jeanne T Paz,Eric Hou Jen Wang,Corrine Badgely,Andrew Olson,Kristina D Micheva,Gordon Wang,Robin Lemmens,Kevin V Tran,Yasuhiro Nishiyama,Xibin Liang,Scott A Hamilton,Nancy O'Rourke,Stephen J Smith,John R Huguenard,Tonya M Bliss,Gary K SteinbergPubMed 26685158
- Proceedings of the National Academy of Sciences of 112:8124-92015Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJung Hoon Shin et. al.PubMed 26080439
- Neuropharmacology 93:171-1782015Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesE D Zarnowska et. al.PubMed 25680234
- Journal of neurophysiology 112:3012-222014Homeostatic plasticity induced by brief activity deprivation enhances long-term potentiation in the mature rat hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesA Félix-Oliveira et. al.PubMed 25210161
- The Journal of physiology 592:4277-952014Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMartina Perin et. al.PubMed 25085886
- The Journal of neuroscience : the official journal of the Society for Neuroscience 34:3183-922014Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMartín F Adrover,Jung Hoon Shin,Veronica A AlvarezPubMed 24573277
- The Journal of neuroscience : the official journal of the Society for Neuroscience 34:1057-662014Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYonatan M Kupchik,Michael D Scofield,Kenner C Rice,Kejun Cheng,Bernard P Roques,Peter W KalivasPubMed 24431463
Key facts
- CAS number
- 492-27-3
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 189.17 Da
- Molecular formula
- C10H7NO3
- PubChem identifier
- 3845
- Nature
- Synthetic
Target data
Alternative names
AHR_HUMAN, AW490526, Ah receptor, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Chi-1, Class E basic helix-loop-helix protein 76, EB11, EIEE27, EPND, FESD, G-protein coupled receptor 35, GLUR, GPR35_HUMAN, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GluN1, GluN2A, GluN2C, GluN2D, GluN3B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate [NMDA] receptor subunit 3A, Glutamate [NMDA] receptor subunit 3B, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, HGNC:348, KYNA receptor, Kynurenic acid receptor, LKS, MGC142178, MGC142180, MRD6, MRD8, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subtype 3A, N-methyl-D-aspartate receptor subtype 3B, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMD3A_HUMAN, NMD3B_HUMAN, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3B, NMDA type glutamate receptor subunit NR3B, NMDAR, NMDAR-L, NMDAR-L1, NMDAR2C, NMDAR2D, NMDAR3A, NMDAR3B, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, Probable G protein coupled receptor 35, Probable G protein coupled receptor GPR35, Smp_128940, bHLHe76, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A
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MW 189.17 Da, Purity >99%. Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective *in vivo*. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256).
Key facts
- CAS number
- 492-27-3
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 189.17 Da
- Molecular formula
- C10H7NO3
- PubChem identifier
- 3845
- Nature
- Synthetic
- Solubility
Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM.
- Biochemical name
- Kynurenic acid
- Biological description
Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective *in vivo*. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)
- Canonical SMILES
- C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O
- InChI
- InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
- InChIKey
- HCZHHEIFKROPDY-UHFFFAOYSA-N
- IUPAC name
- 4-oxo-1H-quinoline-2-carboxylic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
2D chemical structure image of ab120064, Kynurenic acid, endogenous ionotropic / nicotinic antagonist
Image from Rudolph S et al., Neuron. 2011;70(5):991-1004. Fig 3.; doi: 10.1016/j.neuron.2011.03.029 with permission from Elsevier.Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, NBQX, AMPA / kainate antagonist ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency.
D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, NBQX, AMPA / kainate antagonist ab120045) in 2.5 mM external Ca2+.
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