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AB120064

Kynurenic acid, endogenous ionotropic / nicotinic antagonist

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(28 Publications)

MW 189.17 Da, Purity >99%. Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective *in vivo*. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256).
2 Images
Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (AB120064)
  • FuncS

PubMed

Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (AB120064)

C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.

Image from Rudolph S et al., Neuron. 2011;70(5):991-1004. Fig 3.; doi: 10.1016/j.neuron.2011.03.029 with permission from Elsevier.

Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (AB120064)
  • Chemical Structure

Lab

Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (AB120064)

2D chemical structure image of ab120064, Kynurenic acid, endogenous ionotropic / nicotinic antagonist

Key facts

CAS number

492-27-3

Purity

>99%

Form

Solid

form

Molecular weight

189.17 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>7</sub>NO<sub>3</sub>

PubChem

3845

Nature

Synthetic

Solubility

Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM

Biochemical name

Kynurenic acid

Biological description

Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective *in vivo*. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)

Canonical smiles

C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O

InChi

InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

InChiKey

HCZHHEIFKROPDY-UHFFFAOYSA-N

IUPAC Name

4-oxo-1H-quinoline-2-carboxylic acid

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

  • 0
  • 0
Primary Antibodies

AB68428

Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker (AB68428)

  • 5
  • 20
Primary Antibodies

AB9774

Anti-Endothelial Cell antibody [RECA-1]

BOND RX™ Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endothelial Cell antibody [RECA-1] (AB9774)

  • 5
  • 19
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (28)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 6:267 PubMed36918719

2023

Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Yi Chou,Xuhui Cao,Kuan-Chu Hou,Meng-Han Tsai,Chih-Yu Lee,Meng-Fai Kuo,Vin-Cent Wu,Hsin-Yi Huang,Schahram Akbarian,Sheng-Kai Chang,Chung-Yi Hu,Shu-Wha Lin,Hsien-Sung Huang

The Journal of neuroscience : the official journal of the Society for Neuroscience 40:6133-6145 PubMed32631938

2020

Developmentally Transient CB1Rs on Cerebellar Afferents Suppress Afferent Input, Downstream Synaptic Excitation, and Signaling to Migrating Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jesse L Barnes,Claudia Mohr,Caitlin R Ritchey,Chloe M Erikson,Hiroko Shiina,David J Rossi

Nature communications 8:1776 PubMed29176664

2017

GABA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl-sensitive WNK1 kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Heubl,Jinwei Zhang,Jessica C Pressey,Sana Al Awabdh,Marianne Renner,Ferran Gomez-Castro,Imane Moutkine,Emmanuel Eugène,Marion Russeau,Kristopher T Kahle,Jean Christophe Poncer,Sabine Lévi

Brain : a journal of neurology 139:468-80 PubMed26685158

2015

Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target.

Applications

Unspecified application

Species

Unspecified reactive species

Takeshi Hiu,Zoya Farzampour,Jeanne T Paz,Eric Hou Jen Wang,Corrine Badgely,Andrew Olson,Kristina D Micheva,Gordon Wang,Robin Lemmens,Kevin V Tran,Yasuhiro Nishiyama,Xibin Liang,Scott A Hamilton,Nancy O'Rourke,Stephen J Smith,John R Huguenard,Tonya M Bliss,Gary K Steinberg

Proceedings of the National Academy of Sciences of 112:8124-9 PubMed26080439

2015

Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Jung Hoon Shin,Martín F Adrover,Jürgen Wess,Veronica A Alvarez

Neuropharmacology 93:171-178 PubMed25680234

2015

Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor.

Applications

Unspecified application

Species

Unspecified reactive species

E D Zarnowska,F C Rodgers,I Oh,V Rau,C Lor,K T Laha,R Jurd,U Rudolph,E I Eger,R A Pearce

Journal of neurophysiology 112:3012-22 PubMed25210161

2014

Homeostatic plasticity induced by brief activity deprivation enhances long-term potentiation in the mature rat hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

A Félix-Oliveira,R B Dias,M Colino-Oliveira,D M Rombo,A M Sebastião

The Journal of physiology 592:4277-95 PubMed25085886

2014

Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Perin,Fabio Longordo,Christine Massonnet,Egbert Welker,Anita Lüthi

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:3183-92 PubMed24573277

2014

Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine.

Applications

Unspecified application

Species

Unspecified reactive species

Martín F Adrover,Jung Hoon Shin,Veronica A Alvarez

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:1057-66 PubMed24431463

2014

Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum.

Applications

Unspecified application

Species

Unspecified reactive species

Yonatan M Kupchik,Michael D Scofield,Kenner C Rice,Kejun Cheng,Bernard P Roques,Peter W Kalivas
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