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AB120256

Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist

5

(1 Review)

|

(15 Publications)

MW 211.15 Da, Purity >99%. Endogenous antagonist at ionotropic, glycine and α7 nicotinic receptors. Neuroprotective in vivo.
1 Images
Chemical Structure - Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (AB120256)
  • Chemical Structure

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Chemical Structure - Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (AB120256)

2D chemical structure image of ab120256, Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist

Key facts

CAS number

2439-02-3

Purity

>99%

Form

Solid

form

Molecular weight

211.15 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>6</sub>NNaO<sub>3</sub>

PubChem

52974250

Nature

Synthetic

Biochemical name

Kynurenic acid sodium salt

Biological description

Endogenous antagonist at ionotropic, glycine and α7 nicotinic receptors. Neuroprotective in vivo.

Canonical smiles

C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)[O-].[Na+]

InChi

InChI=1S/C10H7NO3.Na/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9;/h1-5H,(H,11,12)(H,13,14);/q;+1/p-1

InChiKey

RCAZGXKUQDXSSK-UHFFFAOYSA-M

IUPAC Name

sodium;4-oxo-1H-quinoline-2-carboxylate

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (15)

Recent publications for all applications. Explore the full list and refine your search

iScience 25:105467 PubMed36388998

2022

Conformational state-dependent regulation of GABA receptor diffusion and subsynaptic domains.

Applications

Unspecified application

Species

Unspecified reactive species

Zaha Merlaud,Xavier Marques,Marion Russeau,Ursula Saade,Maelys Tostain,Imane Moutkine,Marc Gielen,Pierre-Jean Corringer,Sabine Lévi

Cell metabolism 34:1532-1547.e6 PubMed36198294

2022

Hypothalamic astrocytes control systemic glucose metabolism and energy balance.

Applications

Unspecified application

Species

Unspecified reactive species

Daniela Herrera Moro Chao,Matthew K Kirchner,Cuong Pham,Ewout Foppen,Raphael G P Denis,Julien Castel,Chloe Morel,Enrica Montalban,Rim Hassouna,Linh-Chi Bui,Justine Renault,Christine Mouffle,Cristina García-Cáceres,Matthias H Tschöp,Dongdong Li,Claire Martin,Javier E Stern,Serge H Luquet

Neuron 110:841-856.e6 PubMed34982958

2022

Make war not love: The neural substrate underlying a state-dependent switch in female social behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyu Liu,Dong-Wook Kim,Hongkui Zeng,David J Anderson

Neuron 109:1721-1738.e4 PubMed33823137

2021

Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren E McElvain,Yuncong Chen,Jeffrey D Moore,G Stefano Brigidi,Brenda L Bloodgood,Byung Kook Lim,Rui M Costa,David Kleinfeld

Neuron 109:1365-1380.e5 PubMed33740416

2021

Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Waylin Yu,Dipanwita Pati,Melanie M Pina,Karl T Schmidt,Kristen M Boyt,Avery C Hunker,Larry S Zweifel,Zoe A McElligott,Thomas L Kash

Cell 179:713-728.e17 PubMed31626771

2019

Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Wook Kim,Zizhen Yao,Lucas T Graybuck,Tae Kyung Kim,Thuc Nghi Nguyen,Kimberly A Smith,Olivia Fong,Lynn Yi,Noushin Koulena,Nico Pierson,Sheel Shah,Liching Lo,Allan-Hermann Pool,Yuki Oka,Lior Pachter,Long Cai,Bosiljka Tasic,Hongkui Zeng,David J Anderson

eLife 8: PubMed31364987

2019

The readily-releasable pool dynamically regulates multivesicular release.

Applications

Unspecified application

Species

Unspecified reactive species

Jada H Vaden,Gokulakrishna Banumurthy,Eugeny S Gusarevich,Linda Overstreet-Wadiche,Jacques I Wadiche

eLife 8: PubMed30883329

2019

Complementary networks of cortical somatostatin interneurons enforce layer specific control.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander Naka,Julia Veit,Ben Shababo,Rebecca K Chance,Davide Risso,David Stafford,Benjamin Snyder,Andrew Egladyous,Desiree Chu,Savitha Sridharan,Daniel P Mossing,Liam Paninski,John Ngai,Hillel Adesnik

Scientific reports 7:9969 PubMed28855588

2017

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.

Applications

Unspecified application

Species

Unspecified reactive species

Fiona A Bull,Daniel T Baptista-Hon,Jeremy J Lambert,Wendy Walwyn,Tim G Hales

Scientific reports 7:3025 PubMed28596596

2017

Optical mapping of neuronal activity during seizures in zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

L Turrini,C Fornetto,G Marchetto,M C Müllenbroich,N Tiso,A Vettori,F Resta,A Masi,G Mannaioni,F S Pavone,F Vanzi
View all publications

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