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MW 654.72 g/mol, Purity >98%. Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.

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Images

Chemical Structure - L-161,982, EP4 receptor antagonist (AB120947), expandable thumbnail

Key facts

CAS number
147776-06-5
Purity
> 98%
Molecular weight
654.72 g/mol
Nature
Synthetic

Target data

Recommended products

MW 654.72 g/mol, Purity >98%. Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.

Key facts

Purity
> 98%
Solubility

Soluble in DMSO to 10 mM.

Biological description

Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.

Canonical SMILES
CCCCC1NN(C(=O)N1CC1CCC(CC1)C1CCCCC1S(=O)(=O)NC(=O)C1SCCC1C)C1CCCCC1C(F)(F)F
IUPAC name
N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - L-161,982, EP4 receptor antagonist (ab120947), expandable thumbnail

    Chemical Structure - L-161,982, EP4 receptor antagonist (ab120947)

    2D chemical structure image of ab120947, L-161,982, EP4 receptor antagonist

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Product protocols

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