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AB120947

L-161,982, EP4 receptor antagonist

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MW 654.72 g/mol, Purity >98%. Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.
1 Images
Chemical Structure - L-161,982, EP4 receptor antagonist (AB120947)
  • Chemical Structure

Lab

Chemical Structure - L-161,982, EP4 receptor antagonist (AB120947)

2D chemical structure image of ab120947, L-161,982, EP4 receptor antagonist

Key facts

CAS number

147776-06-5

Purity

>98%

Molecular weight

654.72 g/mol

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biological description

Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.

Canonical smiles

CCCCC1NN(C(=O)N1CC1CCC(CC1)C1CCCCC1S(=O)(=O)NC(=O)C1SCCC1C)C1CCCCC1C(F)(F)F

IUPAC Name

N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide

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Biochemicals

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Chemical Structure - Sulprostone, EP1/ EP3 receptor agonist (AB120907)

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Biochemicals

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Biochemicals

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Chemical Structure - Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor (AB141312)

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Biochemicals

AB120905

AH 6809, EP1 and EP2 antagonist

Chemical Structure - AH 6809, EP1 and EP2 antagonist (AB120905)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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