L 701324, glycine site NMDA receptor antagonist
Be the first to review this product! Submit a review
|
(0 Publication)
MW 363.8 Da, Purity >99%. Potent, selective glycine site NMDA receptor antagonist. Shows a reduced propensity to activate mesolimbic dopaminergic systems compared to MK 801 (ab120027). Shows long-acting anticonvulsant effects in vivo. Orally active.
View Alternative Names
AW490526, CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, EB11, EIEE27, EPND, FESD, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GluN1, GluN2A, GluN2C, GluN2D, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, LKS, MGC142178, MGC142180, MRD6, MRD8, Microsomal monooxygenase, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, P450 DB1, P450C2D, Xenobiotic monooxygenase, estrogen receptor binding CpG island, flavoprotein-linked monooxygenase, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A
- Chemical Structure
Lab
Chemical Structure - L 701324, glycine site NMDA receptor antagonist (AB146300)
2D chemical structure image of ab146300, L 701324, glycine site NMDA receptor antagonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NMDA receptors serve as critical components for excitatory neurotransmission in the brain. As part of a larger receptor complex they allow for calcium entry upon activation by glutamate and co-agonists like glycine. This action triggers downstream signaling pathways that influence synaptic plasticity essential for processes like learning and memory. The interaction between different subunits provides specificity in receptor assembly and function enabling varying receptor responses to synaptic events. For instance subunit composition can determine the receptor's open probability and response to antagonists.
Pathways
NMDA receptors integrate into the central signaling pathways of neuronal communication and plasticity particularly in processes like long-term potentiation (LTP). The receptor's activation leads to the opening of calcium channels allowing calcium influx into the neurons which then engages signaling proteins such as CaMKII and calcineurin. These signaling pathways orchestrate changes that strengthen or modify synaptic connections. The NMDA receptor activity complements the functions of other neurotransmitter systems like the AMPA receptor pathway highlighting the receptor's involvement in synaptic plasticity and overall brain function.
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com