MW 436.21 g/mol, Purity >99%.
Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
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Publications
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- Acta pharmaceutica Sinica. B 12:2429-24422022Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDong Liang,Chen Yu,Zhao Ma,Xingye Yang,Zhenzhen Li,Xuhui Dong,Xiaojun Qin,Lupei Du,Minyong LiPubMed 35646536
- Scientific reports 11:18432021Photoperiodic regulation of dopamine signaling regulates seasonal changes in retinal photosensitivity in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKousuke Okimura et. al.PubMed 33469071
Key facts
- CAS number
- 866021-03-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 436.21 g/mol
- Nature
- Synthetic
Recommended products
MW 436.21 g/mol, Purity >99%.
Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
Key facts
- CAS number
- 866021-03-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 436.21 g/mol
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biological description
Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
- IUPAC name
- 3-[4-(4-Chlorophenyl)piperazin-1-yl]-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - L-745870 trihydrochloride, brain penetrant D4 antagonist (ab120598)
2D chemical structure image of ab120598, L-745870 trihydrochloride, brain penetrant D4 antagonist
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