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AB120002

L-AP4, group III mGlu agonist

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(22 Publications)

MW 183.1 Da, Purity >99%. Selective group III mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.
1 Images
Chemical Structure - L-AP4, group III mGlu agonist (AB120002)
  • Chemical Structure

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Chemical Structure - L-AP4, group III mGlu agonist (AB120002)

2D chemical structure image of ab120002, L-AP4, group III mGlu agonist

Key facts

CAS number

23052-81-5

Purity

>99%

Form

Solid

form

Molecular weight

183.1 Da

Molecular formula

C<sub>4</sub>H<sub>1</sub><sub>0</sub>NO<sub>5</sub>P

PubChem

179394

Nature

Synthetic

Biochemical name

(2S)-2-amino-4-phosphonobutanoic acid

Biological description

Selective group III mGlu agonist.

Canonical smiles

C(CP(=O)(O)O)C(C(=O)O)N

Isomeric smiles

C(CP(=O)(O)O)[C@@H](C(=O)O)N

InChi

InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1

InChiKey

DDOQBQRIEWHWBT-VKHMYHEASA-N

IUPAC Name

(2S)-2-amino-4-phosphonobutanoic acid

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Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

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Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

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Biochemicals

AB120059

(S)-MCPG, Group I / II mGlu antagonist

Chemical Structure - (S)-MCPG, Group I / II mGlu antagonist (AB120059)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (22)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Methods & clinical development 30:1-13 PubMed37324975

2023

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.

Applications

Unspecified application

Species

Unspecified reactive species

Yusaku Katada,Hiromitsu Kunimi,Naho Serizawa,Deokho Lee,Kenta Kobayashi,Kazuno Negishi,Hideyuki Okano,Kenji F Tanaka,Kazuo Tsubota,Toshihide Kurihara

Biology of reproduction 107:916-927 PubMed35746896

2022

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Špirková,Veronika Kovaříková,Zuzana Šefčíková,Jozef Pisko,Martina Kšiňanová,Juraj Koppel,Dušan Fabian,Štefan Čikoš

Cell reports 35:109022 PubMed33882303

2021

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors.

Applications

Unspecified application

Species

Unspecified reactive species

Joana Ribeiro,Christopher A Procyk,Emma L West,Michelle O'Hara-Wright,Monica F Martins,Majid Moshtagh Khorasani,Aura Hare,Mark Basche,Milan Fernando,Debbie Goh,Neeraj Jumbo,Matteo Rizzi,Kate Powell,Menahil Tariq,Michel Michaelides,James W B Bainbridge,Alexander J Smith,Rachael A Pearson,Anai Gonzalez-Cordero,Robin R Ali

Current biology : CB 29:763-774.e5 PubMed30799247

2019

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

Applications

Unspecified application

Species

Unspecified reactive species

Víctor Pérez-Fernández,Nina Milosavljevic,Annette E Allen,Kirstan A Vessey,Andrew I Jobling,Erica L Fletcher,Paul P Breen,John W Morley,Morven A Cameron

Nature communications 8:1813 PubMed29180667

2017

Rods progressively escape saturation to drive visual responses in daylight conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Tikidji-Hamburyan,Katja Reinhard,Riccardo Storchi,Johannes Dietter,Hartwig Seitter,Katherine E Davis,Saad Idrees,Marion Mutter,Lauren Walmsley,Robert A Bedford,Marius Ueffing,Petri Ala-Laurila,Timothy M Brown,Robert J Lucas,Thomas A Münch

Nature chemical biology 10:813-5 PubMed25173999

2014

An allosteric modulator to control endogenous G protein-coupled receptors with light.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Pittolo,Xavier Gómez-Santacana,Kay Eckelt,Xavier Rovira,James Dalton,Cyril Goudet,Jean-Philippe Pin,Artur Llobet,Jesús Giraldo,Amadeu Llebaria,Pau Gorostiza

PloS one 9:e106148 PubMed25165854

2014

Step-by-step instructions for retina recordings with perforated multi electrode arrays.

Applications

Unspecified application

Species

Unspecified reactive species

Katja Reinhard,Alexandra Tikidji-Hamburyan,Hartwig Seitter,Saad Idrees,Marion Mutter,Boris Benkner,Thomas A Münch

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:79-94 PubMed24381270

2014

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.

Applications

Unspecified application

Species

Unspecified reactive species

Shen Yin,Meredith J Noetzel,Kari A Johnson,Rocio Zamorano,Nidhi Jalan-Sakrikar,Karen J Gregory,P Jeffrey Conn,Colleen M Niswender

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:18951-65 PubMed24285900

2013

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Bruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmann,Fanny Malhaire,Eric Chapuy,Youssef Aissouni,Monique Etienne,Emmanuel Bourinet,Francine Acher,Jean-Philippe Pin,Alain Eschalier,Cyril Goudet

The Journal of pharmacology and experimental therapeutics 344:624-36 PubMed23257312

2012

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization.

Applications

Unspecified application

Species

Unspecified reactive species

Mikhail Kalinichev,Mélanie Rouillier,Francoise Girard,Isabelle Royer-Urios,Bruno Bournique,Terry Finn,Delphine Charvin,Brice Campo,Emmanuel Le Poul,Vincent Mutel,Sonia Poli,Stuart A Neale,Thomas E Salt,Robert Lütjens
View all publications
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