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AB144481

L-AP4 (mM/ml), group III mGlu agonist

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(13 Publications)

MW 183.1 Da, Purity >99%. Selective group III mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.
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Chemical Structure - L-AP4 (mM/ml), group III mGlu agonist (AB144481)
  • Chemical Structure

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Chemical Structure - L-AP4 (mM/ml), group III mGlu agonist (AB144481)

2D chemical structure image of ab144481, L-AP4 (mM/ml), group III mGlu agonist

Key facts

CAS number

23052-81-5

Purity

>99%

Form

Solid

form

Molecular weight

183.1 Da

Molecular formula

C<sub>4</sub>H<sub>1</sub><sub>0</sub>NO<sub>5</sub>P

PubChem

179394

Nature

Synthetic

Biochemical name

(2S)-2-amino-4-phosphonobutanoic acid

Biological description

Selective group III mGlu agonist.

Canonical smiles

C(CP(=O)(O)O)C(C(=O)O)N

Isomeric smiles

C(CP(=O)(O)O)[C@@H](C(=O)O)N

InChi

InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1

InChiKey

DDOQBQRIEWHWBT-VKHMYHEASA-N

IUPAC Name

(2S)-2-amino-4-phosphonobutanoic acid

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Complementary Products

Biochemicals

AB120002

L-AP4, group III mGlu agonist

Chemical Structure - L-AP4, group III mGlu agonist (AB120002)

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Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

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Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

The Journal of pharmacology and experimental therapeutics 344:624-36 PubMed23257312

2012

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization.

Applications

Unspecified application

Species

Unspecified reactive species

Mikhail Kalinichev,Mélanie Rouillier,Francoise Girard,Isabelle Royer-Urios,Bruno Bournique,Terry Finn,Delphine Charvin,Brice Campo,Emmanuel Le Poul,Vincent Mutel,Sonia Poli,Stuart A Neale,Thomas E Salt,Robert Lütjens

The Journal of physiology 591:303-25 PubMed23045347

2012

Inhibitory mechanisms that generate centre and surround properties in ON and OFF brisk-sustained ganglion cells in the rabbit retina.

Applications

Unspecified application

Species

Unspecified reactive species

Ilya Buldyrev,W Rowland Taylor

The Journal of neuroscience : the official journal of the Society for Neuroscience 32:3842-7 PubMed22423104

2012

Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release.

Applications

Unspecified application

Species

Unspecified reactive species

Boris P Klyuch,Nicholas Dale,Mark J Wall

FASEB journal : official publication of the Federa 26:1682-93 PubMed22223752

2012

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.

Applications

Unspecified application

Species

Unspecified reactive species

Cyril Goudet,Bruno Vilar,Tiphanie Courtiol,Thierry Deltheil,Thomas Bessiron,Isabelle Brabet,Nadia Oueslati,Delphine Rigault,Hugues-Olivier Bertrand,Heather McLean,Hervé Daniel,Marianne Amalric,Francine Acher,Jean-Philippe Pin

Proceedings of the National Academy of Sciences of 108:15480-5 PubMed21896740

2011

Interdomain movements in metabotropic glutamate receptor activation.

Applications

Unspecified application

Species

Unspecified reactive species

Siluo Huang,Jianhua Cao,Ming Jiang,Gilles Labesse,Jianfeng Liu,Jean-Philippe Pin,Philippe Rondard

Neuropharmacology 61:880-8 PubMed21693125

2011

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Alison Atterbury,Mark J Wall

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:8669-80 PubMed21653871

2011

mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Adam C Errington,Giuseppe Di Giovanni,Vincenzo Crunelli,David W Cope

Neuropsychopharmacology : official publication of 36:1599-607 PubMed21451497

2011

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Heather B Gosnell,Yuval Silberman,Brad A Grueter,Robert M Duvoisin,Jacob Raber,Danny G Winder

Journal of medicinal chemistry 53:2797-813 PubMed20218620

2010

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Applications

Unspecified application

Species

Unspecified reactive species

Chelliah Selvam,Nadia Oueslati,Isabelle A Lemasson,Isabelle Brabet,Delphine Rigault,Tiphanie Courtiol,Sara Cesarini,Nicolas Triballeau,Hugues-Olivier Bertrand,Cyril Goudet,Jean-Philippe Pin,Francine C Acher

Molecular pharmacology 77:459-68 PubMed20026717

2009

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.

Applications

Unspecified application

Species

Unspecified reactive species

Colleen M Niswender,Kari A Johnson,Nicole R Miller,Jennifer E Ayala,Qingwei Luo,Richard Williams,Samir Saleh,Darren Orton,C David Weaver,P Jeffrey Conn
View all publications
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